LIMPII/SR-B2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LIMPII (Lysosomal Integral Membrane Protein II), also known as LPG85 (85 kDa lysosomal membrane sialoglycoprotein) and CD36 antigen-like 2 (CD36L2), is a major lysosomal membrane protein. It belongs to the scavenger receptor class B subfamily and is designated member 2 (SR-B2). Other mammalian members of this family include SR-B1 (alternatively known as Cla-1 and CD36L1), and SR-B3 (CD36) (1‑3). SR-B/CD36 family members are type III integral membrane proteins with an N‑ as well as a C-terminal cytoplasmic tail, and a large extracellular (or luminal in the case of LIMPII) loop containing similarly spaced cysteine residues and multiple glycosylation sites. The C-terminal cytoplasmic tail has a di-leucine-based motif that mediates effective lysosomal targeting. LIMPII is expressed on all tissues and cell types examined so far, including activated platelets. LIMPII binds thrombospondin-1, but the biological significance of this interaction is not known. LIMPII‑thrombospondin interaction may contribute to the pro-adhesive changes of activated platelets during coagulation and inflammation (1). Overexpression of LIMPII causes an enlargement of early and late endosomes, suggesting that LIMPII may play a role in lysosome/endosome biogenesis (4). Mice deficient in LIMPII are impaired in membrane transport processes, resulting in ureteric pelvic junction obstruction, deafness and peripheral neuropathy (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ELISA Detection, IHC, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF1888	Applications	Species
AM Collin, M Lecocq, S Noel, B Detry, FM Carlier, F Aboubakar, C Bouzin, T Leal, M Vermeersch, V De Rose, L Regard, C Martin, PR Burgel, D Hoton, S Verleden, A Froidure, C Pilette, S Gohy Lung immunoglobulin A immunity dysregulation in cystic fibrosis EBioMedicine, 2020-09-11;60(0):102974. 2020-09-11 [PMID: 32927272] (ELISA Detection, Mouse)	ELISA Detection	Mouse
Roet KC, Franssen EH, de Bree FM et al. A Multilevel Screening Strategy Defines a Molecular Fingerprint of Proregenerative Olfactory Ensheathing Cells and Identifies SCARB2, a Protein That Improves Regenerative Sprouting of Injured Sensory Spinal Axons. J Neurosci 7/3/2013 [PMID: 23825416]
Casado M, Huerta L, Ortiz A, Perez-Crespo M, Gutierrez-Adan A, Kraemer F, Lasuncion M, Busto R, Martin-Hidalgo A HSL-knockout mouse testis exhibits class B scavenger receptor upregulation and disrupted lipid raft microdomains. J Lipid Res, 2012-09-17;53(12):2586-97. 2012-09-17 [PMID: 22988039] (IHC, Mouse)	IHC	Mouse
Yamayoshi S, Koike S Identification of a Human SCARB2 Region That Is Important for Enterovirus 71 Binding and Infection. J. Virol., 2011-03-09;85(10):4937-46. 2011-03-09 [PMID: 21389126] (Western Blot, Mouse)	Western Blot	Mouse

Array AF1888

• LIMPII/SR-B2 Antibodies
• LIMPII/SR-B2 Lysate
• LIMPII/SR-B2 Proteins
• LIMPII/SR-B2 Proteins and Enzymes