LDLR Antibody (C7) [DyLight 550]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

In cholesterol homeostasis regulation, the low density lipoprotein receptor is a critical factor. LDLR binds and internalizes LDL, then directs LDL toward cellular synthetic machinery, or towards destructive pathways for release or recycling. When alternatively spliced forms of the LDLR are present in cells, its native enzymatic activity is often reduced. This reduction in enzyme function is often related to the formation of atherosclerotic plaques. A common Class 5 mutation in LDLR results in it being able to bind and internalize LDL, but subsequently unable to release it to endosomes for recycling. LDLR is dependent upon the activity of PCSK9 for regulating its activity. In the liver, the LDLR is degraded when signaled by PCSK9, which increases the probability of high hepatic levels of LDL. In the brain, PCSK9 downregulates LDLR levels during development and following adult brain injury, thus demonstrating the dual functionality of this critical receptor.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-78159R

• LDLR Antibodies
• LDLR Antibody Pair
• LDLR ELISA Kit
• LDLR Lysate
• LDLR Proteins
• LDLR ELISAs
• LDLR Proteins and Enzymes