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LDLR Antibody (C7) [Biotin]

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Product Details

Summary
Reactivity Hu, Rt, Po, BvSpecies Glossary
Applications WB, ELISA, Flow, Func, ICC/IF, IHC, IP, MS
Clone
C7
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

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LDLR Antibody (C7) [Biotin] Summary

Immunogen
Partially purified bovine LDL receptor [Swiss-Prot# P01131].
Localization
Cell membrane/cell surface, endomembrane system, endosomes, lysosome, clathrin-coated pit, and Golgi apparatus
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
LDLR
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Electron Microscopy
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • In vitro assay
  • Proximity Ligation Assay
  • Radioimmunoassay
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for LDLR Antibody (C7) [Biotin]

  • FH
  • FHC
  • LDL R
  • LDL receptor
  • LDLCQ2
  • LDLR
  • low density lipoprotein receptor
  • low-density lipoprotein receptor class A domain-containing protein 3
  • low-density lipoprotein receptor

Background

In cholesterol homeostasis regulation, the low density lipoprotein receptor is a critical factor. LDLR binds and internalizes LDL, then directs LDL toward cellular synthetic machinery, or towards destructive pathways for release or recycling. When alternatively spliced forms of the LDLR are present in cells, its native enzymatic activity is often reduced. This reduction in enzyme function is often related to the formation of atherosclerotic plaques. A common Class 5 mutation in LDLR results in it being able to bind and internalize LDL, but subsequently unable to release it to endosomes for recycling. LDLR is dependent upon the activity of PCSK9 for regulating its activity. In the liver, the LDLR is degraded when signaled by PCSK9, which increases the probability of high hepatic levels of LDL. In the brain, PCSK9 downregulates LDLR levels during development and following adult brain injury, thus demonstrating the dual functionality of this critical receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol LDLR