LC3B Antibody - BSA Free

Autophagy (macroautophagy) is a catabolic process which targets intracellular components such as proteins and organelles for degradation. Originally described as a bulk degradation process, current research supports its selective nature (1). Selective autophagy targets specific cellular components for degradation including the endoplasmic reticulum (2) (ER-phagy), mitochondria (3) (mitophagy), peroxisomes (3) (pexophagy), ribosomes (4) (ribophagy) and bacteria (5) (xenophagy). Autophagy relies on a newly formed phagophore, a membrane structure which elongates, sequesters cellular content, and fuses to form a double membrane vesicle known as the autophagosome. Fusion of autophagosomes with lysosomes gives rise to the autophagolysosome, where cellular components are degraded by lysosome hydrolases (1).

Autophagic flux is supported by autophagy-related proteins (Atgs) initially identified in yeast (6,7). The core autophagy machinery is comprised of 17 Atg proteins that play specific roles in autophagosome formation. Among these Atg proteins, Atg8 is not only involved in autophagosome formation but also functions in cargo selection. In mammals, several Atg8 homologues have been identified including microtubule-associated protein 1 light chain 3 alpha, beta and gamma - LC3A, LC3B, and LC3C (8) respectively, as well as GABA type A receptor-associated protein (GABARAP), GABARAP-Like1, and GABARAP-Like2 (9). LC3 (predicted molecular weight 14kD) is ubiquitously expressed and undergoes posttranslational processing after synthesis. First, the cysteine protease Atg4 cleaves a carboxy terminal sequence to generate the cytosolic form LC3-I. Next, E1-like (Atg7) and E2-like (Atg3) enzymes conjugate phosphatidylethanolamine to the newly exposed carboxyterminal glycine, generating LC3-II. Finally, the Atg12-Atg5-Atg16L1 complex participates in LC3 lipidation and autophagosome formation (10). LC3B-I to LC3B-II conversion correlates with autophagosome number and is considered the best marker to monitor autophagy.

References

1. Yu, L., Chen, Y., & Tooze, S. A. (2018). Autophagy pathway: Cellular and molecular mechanisms. Autophagy. https://doi.org/10.1080/15548627.2017.1378838

2. Forrester, A., De Leonibus, C., Grumati, P., Fasana, E., Piemontese, M., Staiano, L., ... Settembre, C. (2019). A selective ER -phagy exerts procollagen quality control via a Calnexin- FAM 134B complex. The EMBO Journal. https://doi.org/10.15252/embj.201899847

3. He, X., Zhu, Y., Zhang, Y., Geng, Y., Gong, J., Geng, J., ... Zhong, H. (2019). RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation. The EMBO Journal. https://doi.org/10.15252/embj.2018100978

4. Mathai, B., Meijer, A., & Simonsen, A. (2017). Studying Autophagy in Zebrafish. Cells. https://doi.org/10.3390/cells6030021

5. Losier, T. T., Akuma, M., McKee-Muir, O. C., LeBlond, N. D., Suk, Y., Alsaadi, R. M., ... Russell, R. C. (2019). AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. Cell Reports. https://doi.org/10.1016/j.celrep.2019.01.062

6. Nakatogawa, H., Suzuki, K., Kamada, Y., & Ohsumi, Y. (2009). Dynamics and diversity in autophagy mechanisms: Lessons from yeast. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm2708

7. Tsukada, M., & Ohsumi, Y. (1993). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Letters. https://doi.org/10.1016/0014-5793(93)80398-E

8. Wild, P., McEwan, D. G., & Dikic, I. (2014). The LC3 interactome at a glance. Journal of Cell Science. https://doi.org/10.1242/jcs.140426

9. Igloi, G. L. (2001). Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABAA receptor-associated protein. Genomics. https://doi.org/10.1006/geno.2001.6555

10. Glick, D., Barth, S., & Macleod, K. F. (2010). Autophagy: Cellular and molecular mechanisms. Journal of Pathology. https://doi.org/10.1002/path.2697

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 9 confirmed species: Human, Mouse, Rat, Bacteria, Bovine, Canine, Porcine, Primate, Zebrafish.

We have publications tested in 19 applications: B/N, Block/Neutralize, EM, FLOW, IB, ICC, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-FrFl, IHC-P, IP, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, In vivo assay, KD, WB, Western Blot.

Showing Publications 1 - 10 of 430. Show All 430 Publications. Collapse Publications.

Publications using NB600-1384	Applications	Species
Vicente GP, Della Salda L, Strefezzi RF. Beclin-1 and LC3B expression in canine mast cell tumours: an immuno-ultrastructural and immunohistochemical study of autophagy The Veterinary Quarterly 2024-11-01 [PMID: 39483060]
Dong Kyu Kim, Kyujin Suh, Junho Park, Sang-Eun Lee, Jihui Han, Sunghoe Chang, Youngsoo Kim, Inhee Mook-Jung FGFR3 drives A beta -induced tau uptake. Experimental & molecular medicine 2024-07-01 [PMID: 38951140]
Jun Yeob Kim, Young Jin Min, Min-Hyeok Lee, Yea Rim An, Hassan Ashktorab, Duane T. Smoot, Sung Won Kwon, Suk Kyeong Lee Ceramide promotes lytic reactivation of Epstein-Barr virus in gastric carcinoma Journal of Virology 2024-02-01 [PMID: 38197630]
Frendo-Cumbo S Identification of New IRS1 Interactors in the Regulation of Insulin Signalling and Cell Proliferation Thesis 2021-01-01 (WB)	WB
Diana Romenskaja, Ugnė Jonavičė, Augustas Pivoriūnas Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms. The FEBS journal 2024-06-05 [PMID: 38840471]
Mireia S. Puig-Segui, Carolyn J. Decker, Hanna Barlit, Vyacheslav M. Labunskyy, Roy Parker, Sergi Puig Regulation of translation in response to iron deficiency in human cells Scientific Reports 2024-04-11 [PMID: 38605136]
Hideki Nonaka, Takayuki Kondo, Mika Suga, Ryu Yamanaka, Yukako Sagara, Kayoko Tsukita, Naoko Mitsutomi, Kengo Homma, Ryuta Saito, Fumihiko Miyoshi, Hiromitsu Ohzeki, Masahiro Okuyama, Haruhisa Inoue Induced pluripotent stem cell‐based assays recapture multiple properties of human astrocytes Journal of Cellular and Molecular Medicine 2024-03-20 [PMID: 38509731]
Spinello, I;Saulle, E;Quaranta, MT;Pelosi, E;Castelli, G;Cerio, A;Pasquini, L;Morsilli, O;Dupuis, ML;Labbaye, C; AC-73 and Syrosingopine Inhibit SARS-CoV-2 Entry into Megakaryocytes by Targeting CD147 and MCT4 Viruses 2024-01-04 [PMID: 38257782]
Rasmus Berglund, Yufei Cheng, Eliane Piket, Milena Z. Adzemovic, Manuel Zeitelhofer, Tomas Olsson, Andre Ortlieb Guerreiro-Cacais, Maja Jagodic The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34 Nature Communications 2024-01-09 [PMID: 38195627]
Meenakshisundaram Balasubramaniam, Jagadeesh Narasimhappagari, Ling Liu, Akshatha Ganne, Srinivas Ayyadevara, Ramani Atluri, Haarika Ayyadevara, Guy Caldwell, Robert J Shmookler Reis, Steven W Barger, W Sue T Griffin Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules. Communications biology 2024-01-10 [PMID: 38191671]
H B Madsen, J H Park, X Chu, Y Hou, Z Li, L J Rasmussen, D L Croteau, V A Bohr, M Akbari The cGAS-STING signaling pathway is modulated by Urolithin A. Mechanisms of ageing and development 2023-12-16 [PMID: 38109974]
Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa, Vladimir Trajkovic Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression PLOS ONE 2023-12-01 [PMID: 38039297]
Toriyama K, Okuma T, Abe S et al. In vitro anticancer effect of azithromycin targeting hypoxic lung cancer cells via the inhibition of mitophagy Oncology letters 2024-01-01 [PMID: 38028184]
Foglio E, D'Avorio E, Vitiello L et al. Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy Cells 2023-11-10 [PMID: 37998340]
Zhang L, Hu Z, Bai W et al. Fucoxanthin ameliorates traumatic brain injury by suppressing the blood-brain barrier disruption iScience 2023-11-01 [PMID: 37965135] (IHC, WB, Mouse) Details: 1:1000 dilution WB, 1:200 dilution IHC	IHC, WB	Mouse
Hurtado KA, Janda J, Schnellmann RG Lasmiditan restores mitochondrial quality control mechanisms and accelerates renal recovery after ischemia-reperfusion injury Biochemical pharmacology 2023-10-21 [PMID: 37866804] (Western Blot, Mouse)	Western Blot	Mouse
Castillo Bautista CM, Eismann K, Gentzel M et al. Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy Cells 2023-09-11 [PMID: 37759469]
Khamis T, Alsemeh AE, Alanazi A et al. Breast Milk Mesenchymal Stem Cells and/or Derived Exosomes Mitigated Adenine-Induced Nephropathy via Modulating Renal Autophagy and Fibrotic Signaling Pathways and Their Epigenetic Regulations Pharmaceutics 2023-08-16 [PMID: 37631363] (Immunohistochemistry)	Immunohistochemistry
Barreca F, Aventaggiato M, Vitiello L et al. SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS Antioxidants (Basel) 2023-08-18 [PMID: 37627630] (Block/Neutralize)	Block/Neutralize
Tamargo-Gómez I, Martínez-García GG, Suárez MF et al. Analysis of ATG4C function in vivo Autophagy 2023-07-17 [PMID: 37459465] (WB, Mouse)	WB	Mouse
Xu Y, Geng Y, Wang H et al. Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury Redox biology 2023-05-30 [PMID: 37290302] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Van Acker ZP, Perdok A, Hellemans R et al. Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism Nature communications 2023-05-24 [PMID: 37225734] (ICC/IF, WB, Human) Details: WB Dilution 1:1000	ICC/IF, WB	Human
Aventaggiato M, Preziosi A, Cheraghi Bidsorkhi H et al. ZnO Nanorods Create a Hypoxic State with Induction of HIF-1 and EPAS1, Autophagy, and Mitophagy in Cancer and Non-Cancer Cells International journal of molecular sciences 2023-04-09 [PMID: 37108134] (WB, Human)	WB	Human
Aventaggiato M, Barreca F, Vitiello L et al. Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery Cells 2023-02-22 [PMID: 36899828] (Western Blot, Mouse)	Western Blot	Mouse
Zhang L, Lin Y, Bai W et al. Human umbilical cord mesenchymal stem cell-derived exosome suppresses programmed cell death in traumatic brain injury via PINK1/Parkin-mediated mitophagy CNS neuroscience & therapeutics 2023-03-08 [PMID: 36890626] (Western Blot, Immunocytochemistry/ Immunofluorescence, Mouse)	Western Blot, Immunocytochemistry/ Immunofluorescence	Mouse
Bjerregaard VA, Levy AM, Batz MS et al. Involvement of Mitochondrial Dysfunction in FOXG1 Syndrome Genes 2023-01-17 [PMID: 36833172] (WB)	WB
Hoffman HK, Prekeris R HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells bioRxiv 2023-02-08 [PMID: 36798155] (ICC/IF, WB)	ICC/IF, WB
Su S, Xue Y, Lee SK et al. A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation Nucleic acids research 2023-02-16 [PMID: 36794732] (WB, Human)	WB	Human
Bhatt V, Lan T, Wang W et al. Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors Cell Death & Disease 2023-01-26 [PMID: 36702816] (Western Blot)	Western Blot
Yamashita G, Takano N, Kazama H et al. p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs Cell death discovery 2022-12-29 [PMID: 36581628] (WB, Human) Details: Dilution used in WB 1:4,000	WB	Human
Miller K, Wagner MA, Jassey A, Jackson WT SNAP23 is essential for germination of EV-D68 replication organelles Virology 2022-12-12 [PMID: 36527930] (WB, Human)	WB	Human
Ye S, Fang L, Xie S et al. Resveratrol alleviates postpartum depression-like behavior by activating autophagy via SIRT1 and inhibiting AKT/mTOR pathway Behavioural brain research 2022-11-07 [PMID: 36356720] (WB, IHC-Fr, Mouse)	WB, IHC-Fr	Mouse
Chumpen Ramirez S, GOmez-SAnchez R, Verlhac P et al. --Atg9 interactions via its transmembrane domains are required for phagophore expansion during autophagy Autophagy 2022-11-10 [PMID: 36354155]
Gross D, Bischof H, Maier S et al. IKCa channels control breast cancer metabolism including AMPK-driven autophagy Cell death & disease 2022-10-27 [PMID: 36302750] (WB, Mouse)	WB	Mouse
Melina Overhoff, Frederik Tellkamp, Simon Hess, Marianna Tolve, Janine Tutas, Marcel Faerfers, Lotte Ickert, Milad Mohammadi, Elodie De Bruyckere, Emmanouela Kallergi, Andrea Delle Vedove, Vassiliki Nikoletopoulou, Brunhilde Wirth, Joerg Isensee, Tim Hucho, Dmytro Puchkov, Dirk Isbrandt, Marcus Krueger, Peter Kloppenburg, Natalia L Kononenko Autophagy regulates neuronal excitability by controlling cAMP /protein kinase A signaling at the synapse The EMBO Journal 2022-10-11 [PMID: 36217825]
Neupane N, Rajendran J, Kvist J et al. Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle Communications biology 2022-10-05 [PMID: 36198903] (WB, Mouse)	WB	Mouse
Khayati K, Bhatt V, Lan T et al. Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer Cancer Research 2022-12-02 [PMID: 36156071] (Western Blot)	Western Blot
Tong F, Xu L, Xu S, Zhang M. Identification of an autophagy-related 12-lncRNA signature and evaluation of NFYC-AS1 as a pro-cancer factor in lung adenocarcinoma Frontiers in Genetics 2022-08-11 [PMID: 36105077] (Immunohistochemistry)	Immunohistochemistry
Park SS, Kim JI, Lee CH et al. Temsirolimus Enhances Anti-Cancer Immunity by Inducing Autophagy-Mediated Degradation of the Secretion of Small Extracellular Vesicle PD-L1 Cancers (Basel) 2022-08-23 [PMID: 36077620]
Khamis T, Alsemeh AE, Abdullah DM Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways Scientific reports 2022-08-27 [PMID: 36030321] (IHC-P, Rat)	IHC-P	Rat
Lee J, Kim SJ, Choi GE et al. Sweet taste receptor agonists attenuate macrophage IL-1 beta expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells Clinical and translational medicine 2022-08-01 [PMID: 35988262] (IHC-P, Mouse) Details: Dilution used 1:400	IHC-P	Mouse
Zhang L, Liu X, Huang M et al. Metformin Inhibits HaCaT Cell Proliferation Under Hyperlipidemia Through Reducing Reactive Oxygen Species via FOXO3 Activation Clinical, Cosmetic and Investigational Dermatology 2022-07-01 [PMID: 35910506] (WB, Human)	WB	Human
Koike T, Takenaka M, Suzuki N et al. Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells Journal of Clinical Biochemistry and Nutrition 2022-01-25 [PMID: 35903602] (Western Blot)	Western Blot
Butera A, Quaranta MT, Crippa L et al. CD147 Targeting by AC-73 Induces Autophagy and Reduces Intestinal Fibrosis Associated with TNBS Chronic Colitis Journal of Crohn's & colitis 2022-07-14 [PMID: 35833587] (WB, Mouse)	WB	Mouse
Lou C, Fang M, Ye S et al. Fluoxetine protects against inflammation and promotes autophagy in mice model of post-traumatic stress disorder Behavioural brain research 2022-07-08 [PMID: 35811001] (WB, Mouse) Details: C57BL/6 Mouse Hippocampus, 1:1000, Fig. 4	WB	Mouse
Davidi S, Jacobovitch S, Shteingauz A et al. Tumor Treating Fields (TTFields) Concomitant with Sorafenib Inhibit Hepatocellular Carcinoma In Vitro and In Vivo Cancers 2022-06-15 [PMID: 35740624] (IHC-P, WB, ICC/IF, Human)	IHC-P, WB, ICC/IF	Human
Kondylis V, Schneider F, Schorn F et al. p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation Cancers 2022-05-15 [PMID: 35626041] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Garavaglia B, Vallino L, Ferraresi A et al. Butyrate Inhibits Colorectal Cancer Cell Proliferation through Autophagy Degradation of ?-Catenin Regardless of APC and ?-Catenin Mutational Status Biomedicines 2022-05-13 [PMID: 35625868] (Western Blot, Immunocytochemistry/ Immunofluorescence)	Western Blot, Immunocytochemistry/ Immunofluorescence
Kumpanat Pomlok, Supansa Pata, Mattapong Kulaphisit, Rachan Pangnuchar, Jiraprapa Wipasa, Duncan R Smith, Watchara Kasinrerk, Pathrapol Lithanatudom An IgM monoclonal antibody against domain 1 of CD147 induces non-canonical RIPK-independent necroptosis in a cell type specific manner in hepatocellular carcinoma cells. Biochimica et biophysica acta. Molecular cell research 2022-09-01 [PMID: 35598753]
Hoch L, Bourg N, Degrugillier F et al. Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination Frontiers in Pharmacology 2022-04-27 [PMID: 35571097]
Yang Yang, Maria Gomez, Timothy Marsh, Laura Poillet-Perez, Akshada Sawant, Lei Chen, Noel R. Park, S. RaElle Jackson, Zhixian Hu, Noa Alon, Chen Liu, Jayanta Debnath, Jun-Lin Guan, Shawn Davidson, Michael Verzi, Eileen White Autophagy in PDGFR alpha + mesenchymal cells is essential for intestinal stem cell survival Proceedings of the National Academy of Sciences of the United States of America 2022-05-10 [PMID: 35537042]
Peugnet V, Chwastyniak M, Mulder P et al. Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes Antioxidants (Basel) 2022-04-06 [PMID: 35453408]
Huo Y, Sawant A, Tan Y et al. Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration PLoS genetics 2022-04-01 [PMID: 35404932] (WB, Human)	WB	Human
Chen H, Zhou J, Chen H et al. Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4 Clinical and translational medicine 2022-04-01 [PMID: 35390228] (IHC-Fr, WB, Human, Mouse)	IHC-Fr, WB	Human, Mouse
De Maziere A, van der Beek J, van Dijk S et al. An optimized protocol for immuno-electron microscopy of endogenous LC3 Autophagy 2022-04-07 [PMID: 35387562] (ICC/IF, Human)	ICC/IF	Human
Ito A, Hashimoto M, Tanihata J et al. Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia Journal of cachexia, sarcopenia and muscle 2022-04-03 [PMID: 35373498] (IF/IHC, Mouse)	IF/IHC	Mouse
Moudio S, Rodin F, Albargothy N et al. Exposure of alpha-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease Frontiers in Neurology 2022-02-16 [PMID: 35309552] (IF/IHC, Rat)	IF/IHC	Rat
Shan Y, Lu C, Wang J et al. IGF-1 contributes to liver cancer development in diabetes patients by promoting autophagy Annals of hepatology 2022-03-13 [PMID: 35297369] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Suliman M, Case K, Schmidtke M et al. Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells Biochim Biophys Acta Mol Cell Biol Lipids 2022-03-05 [PMID: 35247568]
Puertas-Neyra K, Galindo-Cabello N, HernAndez-RodrIguez LA et al. Programmed Cell Death and Autophagy in an in vitro Model of Spontaneous Neuroretinal Degeneration Frontiers in neuroanatomy 2022-02-11 [PMID: 35221932] (IHC-Fr, Porcine)	IHC-Fr	Porcine
Beillevaire D, Migneault F, Turgeon J et al. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes Cell death & disease 2022-02-11 [PMID: 35149669] (WB, Human, Mouse)	WB	Human, Mouse
Lin Q, Cao J, Du X et al. The HeyL-Aromatase Axis Promotes Cancer Stem Cell Properties by Endogenous Estrogen-Induced Autophagy in Castration-Resistant Prostate Cancer Frontiers in oncology 2022-01-12 [PMID: 35096586] (WB, Human)	WB	Human
Thakur AK, Luthra-Guptasarma M Differences in Cellular Clearing Mechanisms of Aggregates of Two Subtypes of HLA-B27 Frontiers in immunology 2022-01-10 [PMID: 35082784] (WB, Human)	WB	Human
Krishnan B, Yasuhara T, Rumde P et al. Active RB causes visible changes in nuclear organization The Journal of cell biology 2022-03-07 [PMID: 35019938] (ICC/IF, Human)	ICC/IF	Human
Sendino GarvI E, Masereeuw R, Janssen MJ Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype Cells 2022-01-05 [PMID: 35011739] (ICC/IF, Human)	ICC/IF	Human
Stempels FC, Janssens MH, Ter Beest M et al. Novel and conventional inhibitors of canonical autophagy differently affect LC3-associated phagocytosis FEBS letters 2022-01-10 [PMID: 35007347] (WB, Human)	WB	Human
Guo Y, Mao R, Xie Q et al. Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection Frontiers in Cell and Developmental Biology 2021-11-18 [PMID: 34869331] (Western Blot)	Western Blot
Xu Y, Hu X, Li F Et al. GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation Oxidative medicine and cellular longevity 2021-10-19 [PMID: 34712387] (Mouse)		Mouse
Pinki Munot, Nadine McCrea, Silvia Torelli, Adnan Manzur, Caroline Sewry, Darren Chambers, Lucy Feng, Pierpaolo Ala, Irina Zaharieva, Nicola Ragge, Helen Roper, Tamas Marton, Phil Cox, Miroslav P Milev, Wen-Chen Liang, Shinsuke Maruyama, Ichizo Nishino, Michael Sacher, Rahul Phadke, Francesco Muntoni TRAPPC11-related muscular dystrophy with hypoglycosylation of alpha-dystroglycan in skeletal muscle and brain. Neuropathology and applied neurobiology 2022-03-31 [PMID: 34648194]
Li R, Hao Y, Wang Q Et al. ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation Cell death & disease 2021-10-06 [PMID: 34615856] (WB, Human)	WB	Human
Smith SJ, Fabian L, Sheikh A Et al. Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy Human molecular genetics 2021-09-25 [PMID: 34568901]
Tu YXI, Sydor AM, Coyaud E et al. Global Proximity Interactome of the Human Macroautophagy Pathway Autophagy 2022-05-04 [PMID: 34524948]
McCarthy CG, Chakraborty S, Singh G et al. Ketone body beta-hydroxybutyrate is an autophagy-dependent vasodilator JCI insight 2021-09-09 [PMID: 34499623] (WB, Rat)	WB	Rat
Miyazaki M, Hiramoto M, Takano N et al. Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics International journal of molecular medicine 2021-10-01 [PMID: 34468012] (WB, Human)	WB	Human
Bellanger D, Dziagwa C, Guimaraes C et al. Adipocytes Promote Breast Cancer Cell Survival and Migration through Autophagy Activation Cancers (Basel) 2021-08-03 [PMID: 34359819] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Hattori K, Takano N, Kazama H et al. Induction of synergistic non apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells Oncology Letters 2021-07-22 [PMID: 34345305] (WB)	WB
Wang X, Zhu Yt, Zhu Y Et Al. Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function Acta pharmacologica Sinica 2021-07-16 [PMID: 34272505] (WB)	WB
Tokarchuk I, Janser Fa, Schlafli Am Et Al. Increased LAMP2A levels correlate with a shorter disease-free survival of HER2 negative breast cancer patients and increased breast cancer cell viability Biochemical and biophysical research communications 2021-07-03 [PMID: 34229122] (WB)	WB
Fontaine A, Bellanger D, Guibon R Et Al. Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue The Journal of pathology 2021-07-05 [PMID: 34219239] (WB)	WB
Akoumianaki T, Vaporidi K, Diamantaki E et al. Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis Cell host & microbe 2021-06-25 [PMID: 34214493]
Devenport SN, Singhal R, Radyk MD et al. Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress JCI insight 2021-06-17 [PMID: 34138755] (IHC-P, Mouse)	IHC-P	Mouse
Araya J, Saito N, Hosaka Y et al. Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis Journal of immunology (Baltimore, Md. : 1950) 2021-06-16 [PMID: 34135057]
Molinari F, Feraco A, Mirabilii S et al. SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes Cells 2021-05-07 [PMID: 34066961] (WB, Mouse)	WB	Mouse
Kazutoshi Toriyama, Naoharu Takano, Hiroko Kokuba, Hiromi Kazama, Shota Moriya, Masaki Hiramoto, Shinji Abe, Keisuke Miyazawa Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells Cancer Science 2021-06-24 [PMID: 34051014]
Orhon I, Rocchi C, Villarejo-Zori B et al. Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal Autophagy 2021-05-19 [PMID: 34009100]
Ferro I, Gavini J, Gallo S et al. The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma Autophagy 2022-01-02 [PMID: 33960270] (In vivo assay)	In vivo assay
Du L, Wu Y, Han X et al. NICE 3 knockdown induces cell cycle arrest and autophagy in lung adenocarcinoma cells via the AKT/mTORC1 signaling pathway Experimental and Therapeutic Medicine 2021-04-15 [PMID: 33936282]
Ovejero-SAnchez M, GonzAlez-Sarmiento R, Herrero AB Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair Neoplasia (New York, N.Y.) 2021-04-27 [PMID: 33930758] (WB, ICC/IF, Human)	WB, ICC/IF	Human
SchlAfli A, Tokarchuk I, Parejo S et al. ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells Scientific Reports 2021-12-01 [PMID: 33907223] (WB, Human)	WB	Human
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Haimovici Aladin, Brigger Daniel, Torbett Bruce E et al. Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation. Leuk Res. 2014-07-01 [PMID: 25043887] (Human)		Human
Li Y, Chen C, Yao F et al. AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1. Arch. Biochem. Biophys. 2014-07-04 [PMID: 25009141] (WB, Rat, Mouse) Details: LC3B antibody used for WB on hearts of male C57BL/6J mice subjected or not (sham) to cardiac hypertrophy induced by pressure overload performed by descending aortic banding/AB (Fig. 1A). Antibody also used for WB on sham or AB groups treated or not with AMPK activator AICAR or metformin. LC3B WB also performed on cultured Rat's cardiomyocytes transfected with Ad-CA-AMPK or Ad-GFP - treated or not with phenylephrine/PE and/or Rapamycin (Fig. 4A, 4C; Fig. 6C).	WB	Rat, Mouse
Brigger D, Proikas-Cezanne T, Tschan MP. WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells. Cell Death Dis 2014-07-04 [PMID: 24991767] (ICC/IF, WB, Human) Details: LC3B antibody used for WB for measuring autophagic flux in SHC002 and shWIPI-1 or shWIPI-2 expressing NB4 cells (human acute promyelocytic leukemic/APL cell lines NB4) upon 1 uM ATRA treatment at day 4 in the presence or absence of bafilomycin A1 (Figure 4a). Antibody also used for ICC-IF application.	ICC/IF, WB	Human
Zhou Y,Sun K,Ma Y et al. Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells Sci Rep. 2014-06-20 [PMID: 24947039] (WB, Human) Details: LC3B antibody used for WB in human hepatocellular carcinoma cells/HCC cell line SMMC-7721 and HepG2 (transiently transfected with GFP-LC3 plasmids) cultured under low glucose and hypoxia (LH) conditions in the presence or absence of CQ or 3-MA for 8 h (Figure 1C).	WB	Human
Sheng R, Zhang TT, Felice VD et al. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J. Biol. Chem. 2014-06-13 [PMID: 24928515] (ICC/IF, IHC-FrFl, Mouse) Details: Used for ICC-IF on murine cortical neurons and IHC-FrFl on mouse brain free floating sections. ICC-IF - Neurons grown on coverglasses fixed for 15 min with 4% PFA and permeablized with PBS/0.1% Triton X-100 for 30 min, blocked with 2% BSA for 1 h at RT, incubated with LC3 (1:800; Novus; NB600-1384) or SPK2 (1:500) at 4°C for 24 h followed by Cy3-conjugated anti-rabbit IgG for 2 h (FIGURE 2A). IHC-FrFl - 24h past isoflurane, C57 mice perfused with PBS/4% PFA-PBS, brains postfixed in 4% PFA/ON, 40 micron-thick coronal sections cut and blocked in 5% normal goat serum, 1% BSA, 0.2% Triton X-100, 0.03% H2O2 in PBS/1 h RT, incubated with 1:800 dilution of LC3-antibody for 48 h at 4C followed by biotinylated anti-rabbit secondary antibody/2 h RT and ABC -DAB detection (FIGURE 6C).	ICC/IF, IHC-FrFl	Mouse
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Stein LR, Imai SI. Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. EMBO J. 2014-05-08 [PMID: 24811750] (WB, Mouse)	WB	Mouse
Stein LR, Wozniak DF, Dearborn JT et al. Expression of nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J. Neurosci. 2014-04-18 [PMID: 24760840] (WB, Mouse)	WB	Mouse
Pang Y, Si M, Sun B et al. DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway. Food Chem. Toxicol. 2014-04-23 [PMID: 24751974] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Meunier E, Dick MS, Dreier RF et al. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014-04-16 [PMID: 24739961] (ICC/IF, Mouse)	ICC/IF	Mouse
Akbari M, Keijzers G, Maynard S et al. Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. DNA Repair (Amst). 2014-02-27 [PMID: 24674627]
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Takasaka N, Araya J, Hara H et al. Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence. J Immunol 2013-12-23 [PMID: 24367027] (WB, Human)	WB	Human
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Huang YL, Chang CL, Tang CH et al. Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. Cell Signal 2013-12-11 [PMID: 24333325] (WB, Human)	WB	Human
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Hung HH, Huang WP, Pan CY. Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival. Cell Biol Toxicol. 2013-09-28 [PMID: 24077806] (WB, Rat)	WB	Rat
Zhirnov OP, Klenk HD. Influenza A virus proteins NS1 and HA along with M2 are involved in stimulation of autophagy in infected cells. J Virol. 2013-09-11 [PMID: 24027311] (WB, Primate, Canine, Human)	WB	Primate, Canine, Human
Hamalainen RH, Manninen T, Koivumaki H et al. Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model. Proc Natl Acad Sci U S A. 2013-09-17 [PMID: 24003133] (ICC/IF, Human)	ICC/IF	Human
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Magnaghi P, D'Alessio R, Valsasina B et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol 2013-07-28 [PMID: 23892893] (WB, Human)	WB	Human
Liu YQ, Ji Y, Li XZ et al. Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro. Acta Pharmacol Sin 2013-07-29 [PMID: 23892275]
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Guo JY, Karsli-Uzunbas G, Mathew R et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev 2013-07-01 [PMID: 23824538] (WB, Mouse)	WB	Mouse
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Ciccia F, Accardo-Palumbo A, Rizzo A et al. Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann Rheum Dis 2013-06-05 [PMID: 23740229]
Clancey LF, Beirl AJ, Linbo TH, Cooper CD. Maintenance of Melanophore Morphology and Survival Is Cathepsin and vps11 Dependent in Zebrafish. PLoS One 2013-05-27 [PMID: 23724125] (WB, Zebrafish)	WB	Zebrafish
Xingyong C, Xicui S, Huanxing S et al. Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats. BMC Neurosci 2013-05-20 [PMID: 23688351] (IHC-Fr, WB, ICC/IF, Rat)	IHC-Fr, WB, ICC/IF	Rat
Kenzelmann Broz D, Spano Mello S, Bieging KT et al. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev 2013-05-01 [PMID: 23651856] (WB, Mouse)	WB	Mouse
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Moriya S, Che XF, Komatsu S et al. Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells. Int J Oncol 2013-05-01 [PMID: 23546223] (WB, Human)	WB	Human
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Selvakumaran M, Amaravadi RK, Vasilevskaya IA, O'Dwyer PJ. Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. Clin Cancer Res 2013-06-01 [PMID: 23461901] (WB, Human)	WB	Human
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Baranski Madrigal Z. Osteosarcoma: searching for new treatment options. Thesis 2016-05-26
Schutz I. Uptake and intracellular delivery of nanoparticles into mammalian cells. Thesis 2016-07-01 (WB, ICC/IF, IF/IHC)	WB, ICC/IF, IF/IHC
Verhaar R, Drukarch B, Bol JG et al. Tissue transglutaminase cross-links beclin 1 and regulates autophagy in MPP+-treated human SH-SY5Y cells. Neurochem Int 2013-02-01 [PMID: 23380076] (WB, Human)	WB	Human
Humbert M, Medova M, Aebersold DM et al. Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells Biochem Biophys Res Commun 2013-01-09 [PMID: 23313490] (WB, Human)	WB	Human
Efeyan A, Zoncu R, Chang S et al. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival Nature 2012-12-23 [PMID: 23263183] (WB, Mouse)	WB	Mouse
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Bess AS, Ryde IT, Hinton DE, Meyer JN. UVC-Induced Mitochondrial Degradation via Autophagy Correlates with mtDNA Damage Removal in Primary Human Fibroblasts J Biochem Mol Toxicol 2012-11-06 [PMID: 23132756] (WB, Human)	WB	Human
Zhang F, Li Y, Tang Z et al. Proliferative and Survival Effects of PUMA Promote Angiogenesis Cell Rep 2012-10-31 [PMID: 23122957] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Gwak HS, Kim TH, Jo GH et al. Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines PLoS One 2012-01-01 [PMID: 23077620] (WB, Human)	WB	Human
Liao CC, Ho MY, Liang SM, Liang CM. Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration. Autophagy. 2013-01-01 [PMID: 23051912]
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Chua JPC. Characterizing molecular modifiers of pathogenesis in spinobulbar muscular atrophy. Thesis. 2015-01-01 (WB, Rat)	WB	Rat
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Dehvari N, Mahmud T, Persson J et al. Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor. Neurochem Int 2012-04-01 [PMID: 22366649] Details: Using the Biotin conjugated version of NB600-1384, catalog number NB600-1384B.
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Dien Bard J, Gelebart P, Anand M et al. IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma. Am J Pathol 2009-08-01 [PMID: 19608866] (ICC/IF, Human)	ICC/IF	Human
Wei J, Fujita M, Nakai M et al. Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. Am J Pathol 2009-05-01 [PMID: 19349362] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Montie HL, Cho MS, Holder L et al. Cytoplasmic retention of polyglutamine-exped rogen receptor ameliorates disease via autophagy in a mouse model of spinal bulbar muscular atrophy. Hum Mol Genet;18(11):1937-1950. 2009-01-01 [PMID: 19279159] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Ulasov IV, Sonabend AM, Nandi S et al. Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo. Br J Cancer 2009-04-07 [PMID: 19277041] (FLOW, IHC-P, Human)	FLOW, IHC-P	Human
Jiang H, White EJ, Conrad C et al. Autophagy pathways in glioblastoma. Methods Enzymol 2009-01-01 [PMID: 19216911]
Gao M, Yeh PY, Lu YS et al. OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Res;68(22):9348-57. 2008-11-15 [PMID: 19010909] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Tafani M, Schito L, Anwar T et al. Induction of autophagic cell death by a novel molecule is increased by hypoxia. Autophagy;4(4):467-75. 2008-01-01 [PMID: 18927491] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Aoki H, Kondo Y, Aldape K et al. Autophagy. Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. 2008-05-16 [PMID: 18259115] (WB, IHC-P, ICC/IF, IHC-Fr, Human)	WB, IHC-P, ICC/IF, IHC-Fr	Human
Pyo JO, Nah J, Kim HJ et al. Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. Autophagy;4(3):315-21. 2008-04-01 [PMID: 18196969]
Show All 430 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Mouse	04/16/2022	View Summary Application Western Blot Sample Tested CT26 cells Species Mouse Lot NB600-1384
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	07/17/2019	View Summary Application Western Blot Sample Tested Bone Marrrow Derived Macrophages Species Mouse Lot CF-1 Comments Comments Secondary antibody used: Alexa Fluor 488
Enlarge	4 reviewed by: Verified Customer	WB	Human	06/04/2018	View Summary Application Western Blot Sample Tested Hek 293T cell lysate Species Human Lot CC-1
Enlarge	5 reviewed by: Bo Ding	WB	Mouse	02/20/2018	View Summary Application Western Blot Sample Tested 20 ug whole cell lysate Species Mouse Lot CJ-1
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	07/22/2016	View Summary Application Western Blot Sample Tested Whole cell lysate Species Mouse Lot BQ
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	06/28/2016	View Summary Application Western Blot Sample Tested mice primary macrophages Species Mouse Lot BO
Enlarge	5 reviewed by: Verified Customer	ICC	Human	02/04/2015	View Summary Application Immunocytochemistry Species Human
	4 reviewed by: Verified Customer	IF	Mouse	12/23/2014	View Summary Application Immunofluorescence Sample Tested See PMID 23525089 Species Mouse
	5 reviewed by: Verified Customer	IF	Rat	12/23/2014	View Summary Application Immunofluorescence Sample Tested See PMID 23688351 Species Rat
Enlarge	5 reviewed by: Verified Customer	WB	Human	11/25/2014	View Summary Application Western Blot Sample Tested IB3-1 whole cell lysate Species Human Lot trial sample
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	11/23/2014	View Summary Application Western Blot Sample Tested mouse hearts Species Mouse
Enlarge	5 reviewed by: Verified Customer	WB	Rat	11/01/2014	View Summary Application Western Blot Sample Tested Rat brain Species Rat
	4 reviewed by: Verified Customer	WB	Mouse	10/03/2014	View Summary Application Western Blot Sample Tested Whole cell lysate alveolar macrophages Species Mouse
Enlarge	4 reviewed by: Mohammad Abedi	WB	Human	07/10/2014	View Summary Application Western Blot Sample Tested Neuroblastoma whole cell lysate Species Human Lot 1384
Enlarge	4 reviewed by: Bryan Tinsley	WB	Human	06/10/2014	View Summary Application Western Blot Species Human
Enlarge	5 reviewed by: Bryan Tinsley	ICC	Human	06/10/2014	View Summary Application Immunocytochemistry Species Human
	3 reviewed by: Verified Customer	IHC	Human	10/19/2010	View Summary Application Immunohistochemistry Sample Tested Human Esophagus tissue Species Human
	2 reviewed by: Verified Customer	IF	Other	08/28/2009	View Summary Application Immunofluorescence Sample Tested Human Oral Keratinocyte Species Other Lot K
	4 reviewed by: Verified Customer	WB	Mouse	05/26/2009	View Summary Application Western Blot Sample Tested mouse liver tissue, Sample Amount: 100 Species Mouse Lot I1

Array NB600-1384

• LC3B Antibodies
• LC3B Proteins