Lamin A + C Antibody

Lamin A and lamin C are alternative splicing products of the lamin A/C gene that is responsible for autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD) (1). Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues. Lamins A and C, the products of the LMNA gene, are nuclear intermediate filament proteins and are the major structural components of the lamina network that underlies and supports the nuclear envelope (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-56649	Applications	Species
Wulff-Fuentes E, Boakye J, Kroenke K et al. O-GlcNAcylation regulates OTX2's proteostasis. iScience 2023-10-01 [PMID: 38026167]
Hinte F, van Anken E, Tirosh B, Brune W Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway PLoS Pathog. 2020-02-01 [PMID: 32092124] (WB, Human)	WB	Human
Kiel T, Busch A, Meyer-Rachner A, Hubner S. Laminopathy-inducing mutations reduce nuclear import of expressed prelamin A. Int. J. Biochem. Cell Biol. 2014-06-03 [PMID: 24943589] (WB, Human) Details: Fig 2D: HeLa cells transfected with various lamin A constructs (Lamin-HeLa). The lamin A/C pAb antibody recognized both endogenous and recombinant lamin A, and detected both pre-lamin A and mature lamin A. The specificity of the Lamin A/C pAb was validated in Lamin-HeLa by WB (Fig 2D).	WB	Human
Nakamura M, Yamada M, Ohsawa T et al. Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. Biochim Biophys Acta. 2006-09-01 [PMID: 16949164]
Lei JX, Liu QY, Sodja C et al. S/MAR-binding properties of Sox2 and its involvement in apoptosis of human NT2 neural precursors. Cell Death Differ. 2005-11-01 [PMID: 15920534]
Siripurapu V, Meth J, Kobayashi N, Hamaguchi M. DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. J Mol Biol. 2005-02-11 [PMID: 15663929]

Array NB100-56649

• Lamin A + C Antibodies
• Lamin A + C Lysates
• Lamin A + C Proteins