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Ku70/XRCC6 Antibody (KU729) [Biotin]

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Product Details

Summary
Reactivity Hu, Pm, Ch(-), Mu(-), Rt(-)Species Glossary
Applications Flow, ICC/IF
Clone
KU729
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-34663AF350
Alexa Fluor 405
NBP2-34663AF405
Alexa Fluor 488
NBP2-34663AF488
Alexa Fluor 532
NBP2-34663AF532
Alexa Fluor 594
NBP2-34663AF594
Alexa Fluor 647
NBP2-34663AF647
Alexa Fluor 700
NBP2-34663AF700
Alexa Fluor 750
NBP2-34663AF750
Allophycocyanin
NBP2-34663APC
CoraFluor 1
NBP2-34663CL1
DyLight 350
NBP2-34663UV
DyLight 405
NBP2-34663V
DyLight 488
NBP2-34663G
DyLight 550
NBP2-34663R
DyLight 594
NBP2-34663DL594
DyLight 650
NBP2-34663C
DyLight 680
NBP2-34663FR
DyLight 755
NBP2-34663IR
FITC
NBP2-34663F
Janelia Fluor 525
NBP2-34663JF525
Janelia Fluor 549
NBP2-34663JF549
Janelia Fluor 585
NBP2-34663JF585
Janelia Fluor 635
NBP2-34663JF635
Janelia Fluor 646
NBP2-34663JF646
Janelia Fluor 669
NBP2-34663JF669
PE
NBP2-34663PE
PerCP
NBP2-34663PCP
Unconjugated
NBP2-34247-0.1mg
mFluor Violet 450 SE
NBP2-34663MFV450
mFluor Violet 500 SE
NBP2-34663MFV500
mFluor Violet 610 SE
NBP2-34663MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-34247-0.1mg
Azide and BSA Free
NBP2-34663-0.1mg
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Ku70/XRCC6 Antibody (KU729) [Biotin] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Nuclear extract of human HL-60 cells
Localization
Nuclear
Marker
Nuclear Marker
Specificity
Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. This monoclonal antibody recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
XRCC6
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow (Intracellular)
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
Readout System

Reactivity Notes

Does not react with Mouse, Rat and Chicken.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Ku70/XRCC6 Antibody (KU729) [Biotin]

  • 5'-deoxyribose-5-phosphate lyase Ku70
  • 5'-dRP lyase Ku70
  • 70 kDa subunit of Ku antigen
  • ATP-dependent DNA helicase 2 subunit 1
  • ATP-dependent DNA helicase II 70 kDa subunit
  • CTC box binding factor 75 kDa subunit
  • CTC box-binding factor 75 kDa subunit
  • CTC75
  • CTCBF
  • D22S731
  • EC 3.6.4.-
  • EC 4.2.99.-
  • G22P1
  • G22P1Ku70
  • Ku autoantigen p70 subunit
  • Ku autoantigen, 70kDa
  • Ku70
  • ML8
  • ML8,70 kDa subunit
  • thyroid-lupus autoantigen p70
  • Thyroid-lupus autoantigen
  • TLAA
  • TLAAD22S671
  • X-ray repair complementing defective repair in Chinese hamster cells 6DNA repair protein XRCC6
  • X-ray repair cross-complementing protein 6
  • XRCC6

Background

The Ku autoantigen is a heterodimer of 70kDa (p70) and ~80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460kDa DNAdependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol XRCC6