KAP1 [p Ser824] Antibody

This antibody can be used as the primary antibody in a PLA assay with the following as complementing antibodies:NB100-322, NB500-158, NB100-41429

The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using NB100-2350	Applications	Species
Martinikova AS The role of truncated PPM1D/Wip1 phosphatase in cancer Thesis 2022-01-01 (WB, Mouse)	WB	Mouse
Alexandra Nguyen, Al-Hassan M. Mustafa, Alessa K. Leydecker, Melisa Halilovic, Janine Murr, Falk Butter, Oliver H. Krämer The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells Cell Communication and Signaling : CCS 2024-04-03 [PMID: 38570831]
Nicole Kiweler, Helena Schwarz, Alexandra Nguyen, Stephanie Matschos, Christina Mullins, Andrea Piée-Staffa, Christina Brachetti, Wynand P. Roos, Günter Schneider, Michael Linnebacher, Walburgis Brenner, Oliver H. Krämer The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil Cell Biology and Toxicology 2022-05-24 [PMID: 35608750]
Yang Y, Lu H, Chen C et al. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia Nature communications 2022-01-14 [PMID: 35031618] (Chemotaxis, WB)	Chemotaxis, WB
Nguyen A, Dzulko M, Murr J et al. Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion Cells 2021-09-23 [PMID: 34685500] (WB)	WB
Iida K, Abdelhamid Ahmed AH, Nagatsuma AK et al. Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate Cancer discovery 2021-02-12 [PMID: 33579785]
Martinikova AS, Burocziova M, Stoyanov M, Macurek L Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma Cells 2020-09-10 [PMID: 32927737] (WB, Mouse)	WB	Mouse
Quek H, Luff J, Cheung K et al. Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. J. Leukoc. Biol. 2016-11-28 [PMID: 27895165] (Rat)		Rat
Hartlerode AJ, Morgan MJ, Wu Y et al. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat. Struct. Mol. Biol. 2015-08-17 [PMID: 26280532] (WB, Mouse)	WB	Mouse
Kijas AW, Lim YC, Bolderson E et al. ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Res. 2015-08-03 [PMID: 26240375] (WB, Human)	WB	Human
Puccini J, Shalini S, Voss AK et al. Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proc Natl Acad Sci U S A 2013-12-03 [PMID: 24248351] (WB, Mouse)	WB	Mouse
Nayler S, Gatei M, Kozlov S et al. Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells: Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype Stem Cells Transl Med 2012-12-01 [PMID: 23197857]
Bhatia N, Xiao TZ, Rosenthal KA et al. MAGE-C2 Promotes Growth and Tumorigenicity of Melanoma Cells, Phosphorylation of KAP1, and DNA Damage Repair J Invest Dermatol 2012-10-25 [PMID: 23096706] (WB, Human)	WB	Human
Yamamoto K, Wang Y, Jiang W et al. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol 2012-08-01 [PMID: 22869596]
Bolderson E, Savage KI, Mahen R et al. Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1beta (HP1-beta) mobilization and DNA repair in heterochromatin. J Biol Chem 2012-08-01 [PMID: 22715096]
Pires IM, Olcina MM, Anbalagan S et al. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. Br J Cancer 2012-07-01 [PMID: 22713662]
Temviriyanukul P, van Hees-Stuivenberg S, Delbos F et al. Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome. DNA Repair (Amst) 2012-06-01 [PMID: 22521143]
Lee DH, Goodarzi AA, Adelmant GO et al. Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J 2012-04-01 [PMID: 22491012]
Xiao TZ, Bhatia N, Urrutia R et al. MAGE I Transcription Factors Regulate KAP1 and KRAB Domain Zinc Finger Transcription Factor Mediated Gene Repression. PLoS ONE. 2011-01-01 [PMID: 21876767]
Gatei M, Jakob B, Chen P et al. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control J Biol Chem 2011-09-09 [PMID: 21757780] (WB, Human)	WB	Human
Sims JK, Wade PA. Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin. Mol Biol Cell. 2011-09-01 [PMID: 21737684]
Du L, Kayali R, Bertoni C et al. Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum Hum Mol Genet 2011-08-15 [PMID: 21576124] (WB, Human)	WB	Human
Bhatia N, Yang B, Xiao TZ et al. Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1 Arch Biochem Biophys 2011-04-15 [PMID: 21277283] (WB, Human)	WB	Human
Forrester NA, Sedgwick GG, Thomas A et al. Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection. J Virol 2011-03-01 [PMID: 21159879]
Jacobs C, Huang Y, Masud T et al. A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet 2011-02-01 [PMID: 21147755]
Kanu et al. J Biol Chem 285 (49):38534-38542. 2010-01-01 [PMID: 20889973]
Gilmore-Hebert M, Ramabhadran R, Stern DF et al. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Mol Cancer Res 2010-10-01 [PMID: 20858735]
So S, Davis AJ, Chen DJ et al. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol 2009-12-01 [PMID: 20026654]
Lovejoy et al. PNAS 106 (46):19304-19309. 2009-01-01 [PMID: 19889979]
Bansbach et al. Genes & Development 23 (20):2405-2414. 2009-01-01 [PMID: 19793861]
Chang et al. Cancer Res 69 (14):5681-5689. 2009-01-01 [PMID: 19584288]
Tomimatsu N, Mukherjee B, Burma S et al. Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep 2009-06-01 [PMID: 19444312]
Helmink BA, Bredemeyer AL, Lee BS et al. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med 2009-03-01 [PMID: 19221393]
Daniel JA, Pellegrini M, Lee JH et al. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol 2008-12-01 [PMID: 19047460]
Bencokova et al. Mol Cell Biol 29 (2):526-537. 2009-01-01 [PMID: 18981219]
Li X, Lee YK, Jeng JC et al. Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. J Biol Chem 2007-12-01 [PMID: 17942393]
Biton S, Gropp M, Itsykson P et al. ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. DNA Repair (Amst) 2007-01-01 [PMID: 17178256]
Show All 37 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Yongkang Yang	WB	Human	10/28/2020	View Summary Application Western Blot Sample Tested MDA-231 cell lysate Species Human Lot A5

Array NB100-2350

• KAP1 Antibodies
• KAP1 ELISA Kit
• KAP1 Lysate
• KAP1 Proteins