HP1 alpha Antibody

HP1 alpha (heterochromatin protein 1 homolog alpha or CBX5) is a component of heterochromatin that recognizes and binds H3K9me (histone H3 tails methylated at 'Lys-9') for facilitating epigenetic repression and is excluded from chromatin once histone H3 is phosphorylated at Tyr 41 position (H3Y41ph). HP1 alpha can interact with LBR (lamin-B receptor) thereby mediating heterochromatin association with inner nuclear membrane and its interaction with MIS12 complex proteins is implicated in functional kinetochore formation. HP1 alpha is a highly conserved nonhistone protein with chromatin organization modifier domain or chromodomain, and is localized in the nucleus where it participates in centromeric/pericentromeric heterochromatin and associates with chromosomes during mitotic metaphase/anaphase facilitating accurate cell division. It also serve as a common gene expression signature shared by human mature oocytes and embryonic stem cells, and through interactions with ATRX as well as H3.3, HP1 alpha acts a key regulator of ES-cell telomere chromatin. HP1 alpha is up-regulated in breast cancer cells and in lung cancer, it is essential to the maintenance of aggressiveness as well as stem cell like properties of tumor cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB100-2518

• HP1 alpha Antibodies
• HP1 alpha Lysates
• HP1 alpha Proteins