INSRR/IR-related receptor Antibody (6E6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesn't bind any of IR and IGF-1R known ligands (1-2). In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using H00003645-M01	Applications	Species
Yamaoka M, Terabayashi T, Nishioka T et al. IRR is involved in glucose-induced endocytosis after insulin secretion. J Pharmacol Sci. 2019-07-05 [PMID: 31353211]

Array H00003645-M01

• INSRR/IR-related receptor Antibodies
• INSRR/IR-related receptor Lysate
• INSRR/IR-related receptor Protein
• INSRR/IR-related receptor Proteins and Enzyme