Recombinant Mouse IL-5 Protein

IL-5, also named B-cell differentiation factor I, eosinophil differentiation factor and TRF, is belonging to the cytokine family and the IL-5 gene is in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in TH2 cells. Through binding to the IL-5 receptor, IL-5 stimulates B cell growth and increases immunroglobulin secretion. It is also a key mediator in eosinophil activation. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. The cDNA for murine IL-5 encodes a signal peptide and a 113 amino acid mature protein. Mature murine IL-5 shares 70 %, 94 %, 58 %, 66 %, 59 % and 63 % a.a. sequence identity with human, rat, canine, equine, feline and porcine IL5, respectively. It shows cross-reactivity with human IL5 receptor.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Publication using NBP2-35132	Applications	Species
Yexian Yuan, Ruoci Hu, Jooman Park, Shaolei Xiong, Zilai Wang, Yanyu Qian, Zuoxiao Shi, Ruifan Wu, Zhenbo Han, Sang-Ging Ong, Shuhao Lin, Krista A. Varady, Pingwen Xu, Daniel C. Berry, Gang Shu, Yuwei Jiang Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure Science Advances 2024-06-28 [PMID: 38924414]

Array NBP2-35132

• IL-5 Antibodies
• IL-5 Antibody Pair
• IL-5 ELISA Kits
• IL-5 Proteins
• IL-5 Proteins and Enzymes
• IL-5 ELISAs