IL-3R alpha/CD123 Antibody (32703) [PerCP (Peridinin-chlorophyll Protein Complex)]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-3 is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors (1, 2). IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123) and a 120-140 kDa IL-3 R beta subunit (CD131) (3, 4). IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta , however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL‑3 R beta chain has a very large cytoplasmic domain. The IL‑3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 8 of 8.

Publications using FAB301C	Applications	Species
Fonseka CL, Hardman CS, Woo J et al. Dengue virus co-opts innate type 2 pathways to escape early control of viral replication Communications biology 7/22/2022 [PMID: 35869167]
Hardman CS, Chen YL, Salimi M et al. IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent Science Immunology 5/28/2021 [PMID: 34021026]
Hardman CS, Chen YL, Salimi M et al. IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent Science Immunology 2021-05-28 [PMID: 34021026]
Clare S. Hardman, Yi-Ling Chen, Maryam Salimi, Rachael Jarrett, David Johnson, Valtteri J. Järvinen et al. CD1a presentation of endogenous antigens by group 2 innate lymphoid cells Science Immunology 12/22/2017 [PMID: 29273672]
Maryam Salimi, Luzheng Xue, Helen Jolin, Clare Hardman, David J. Cousins, Andrew N. J. McKenzie et al. Group 2 innate lymphoid cells express functional NKp30 receptor inducing type 2 cytokine production1 The Journal of Immunology 1/1/2016 [PMID: 26582946]
Sean P. Saunders, Tara Moran, Achilleas Floudas, Felicity Wurlod, Agnieszka Kaszlikowska, Maryam Salimi et al. Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity Journal of Allergy and Clinical Immunology 2/1/2016 [PMID: 26299987]
Xue L, Salimi M, Panse I, Mjosberg J, McKenzie A, Spits H, Klenerman P, Ogg G Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. J Allergy Clin Immunol, 2013-12-31;133(4):1184-94. 12/31/2013 [PMID: 24388011]
Salimi M, Barlow J, Saunders S, Xue L, Gutowska-Owsiak D, Wang X, Huang L, Johnson D, Scanlon S, McKenzie A, Fallon P, Ogg G A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med, 2013-12-09;210(13):2939-50. 2013-12-09 [PMID: 24323357] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB301C

• IL-3R alpha/CD123 Antibodies
• IL-3R alpha/CD123 Antibody Pair
• IL-3R alpha/CD123 ELISA Kits
• IL-3R alpha/CD123 Lysate
• IL-3R alpha/CD123 Proteins
• IL-3R alpha/CD123 Proteins and Enzymes