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IL-13R alpha 2 Antibody (83834) [Unconjugated]

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Western blot shows lysates of human placenta tissue and human testis tissue. PVDF membrane was probed with 5 µg/mL of Mouse Anti-Human IL-13 Ra2 Monoclonal Antibody (Catalog # MAB614) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for IL-13 Ra2 at approximately 50-55 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Western blot shows lysates of human placenta tissue and human testis tissue. PVDF membrane was probed with 5 µg/mL of Mouse Anti-Human IL-13 Ra2 Monoclonal Antibody (Catalog # MAB614) followed by HRP-conjugated ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
83834
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB614-SP
Carrier Free
MAB614-500
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IL-13R alpha 2 Antibody (83834) [Unconjugated] Summary

Specificity
Detects human IL-13 R alpha 2 in direct ELISAs and Western blots. In Western blots, this antibody shows approximately 5% cross‑reactivity with recombinant human (rh) IL‑4 R and rhIL‑9 R and no cross-reactivity with rhIL‑5 R alpha , rhIL‑5 R beta , rhIL‑13 R alpha 1, or recombinant mouse IL‑13 R alpha 2.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL13RA2
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Applications/Dilutions

Dilutions
  • Western Blot 5 ug/mL
Publications
Read Publications using
MAB614 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-13R alpha 2 Antibody (83834) [Unconjugated]

  • cancer/testis antigen 19
  • CD213a2 antigen
  • CD213a2
  • CT19
  • IL-13 R alpha 2
  • IL-13 receptor subunit alpha-2
  • IL13BP
  • IL13R alpha 2
  • IL-13R subunit alpha-2
  • IL13R
  • IL-13R
  • IL13RA2
  • IL-13Ra2
  • IL-13R-alpha-2
  • interleukin 13 binding protein
  • interleukin 13 receptor alpha 2 chain
  • interleukin 13 receptor, alpha 2
  • interleukin-13 receptor subunit alpha-2
  • Interleukin-13-binding protein

Background

Two type I membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with high affinity. The lower affinity IL-13 binding protein is now referred to as IL-13 R alpha 1 and is also known as CD213a. IL-13 R alpha 1 combines with IL-4 R alpha to form a high affinity receptor complex capable of transducing an IL-13-dependent proliferative signal. The higher affinity IL-13 binding protein, now referred to as IL-13 R alpha 2, does not induce a signal and acts as a decoy receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-13R alpha 2 Antibody (MAB614)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ELISA Development, Flow Cytometry, Western Blot.


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ELISA Development
(2)
Flow Cytometry
(1)
Western Blot
(2)
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Human
(4)
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Showing Publications 1 - 8 of 8.
Publications using MAB614 Applications Species
Takahiro Nagai, Naoki Terada, Masato Fujii, Yasuhisa Nagata, Kozue Nakahara, Shoichiro Mukai et al. Identification of the alpha 2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft models Cancer Rep (Hoboken) 2/1/2023 [PMID: 36806727]
Mei Meng Cigarette smoke extracts induce overexpression of the proto-oncogenic gene interleukin-13 receptor ?2 through activation of the PKA-CREB signaling pathway to trigger malignant transformation of lung vascular endothelial cells and angiogenesis Cell. Signal, 2016-12-13;0(0):. 2016-12-13 [PMID: 27986643]
Shibasaki N, Yamasaki T, Kanno T, Arakaki R, Sakamoto H, Utsunomiya N, Inoue T, Tsuruyama T, Nakamura E, Ogawa O, Kamba T Role of IL13RA2 in Sunitinib Resistance in Clear Cell Renal Cell Carcinoma. PLoS ONE, 2015-06-26;10(6):e0130980. 2015-06-26 [PMID: 26114873] (Western Blot, Human) Western Blot Human
Kong S, Sengupta S, Tyler B, Bais A, Ma Q, Doucette S, Zhou J, Sahin A, Carter B, Brem H, Junghans R, Sampath P Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells. Clin Cancer Res, 2012-09-10;18(21):5949-60. 2012-09-10 [PMID: 22966020] (Flow Cytometry, Human) Flow Cytometry Human
Linda C. Hsi, Suman Kundu, Juan Palomo, Bo Xu, Ryan Ficco, Michael A. Vogelbaum et al. Silencing IL-13R alpha 2 Promotes Glioblastoma Cell Death via Endogenous Signaling Molecular Cancer Therapeutics 7/1/2011 [PMID: 21596889]
Hui He, Jianchun Xu, Peter S. Nelson, Fray F. Marshall, Leland W. K. Chung, Haiyen E. Zhau et al. Differential expression of the alpha2 chain of the interleukin-13 receptor in metastatic human prostate cancer ARCaPM cells The Prostate 6/15/2010 [PMID: 20166133]
Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling. J. Immunol., 2006-06-15;176(12):7495-501. 2006-06-15 [PMID: 16751396] (ELISA Development, Human) ELISA Development Human
Trieu Y, Wen XY, Skinnider BF, Bray MR, Li Z, Claudio JO, Masih-Khan E, Zhu YX, Trudel S, McCart JA, Mak TW, Stewart AK Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo. Cancer Res., 2004-05-01;64(9):3271-5. 2004-05-01 [PMID: 15126369] (ELISA Development, Western Blot, Human) ELISA Development, Western Blot Human

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Bioinformatics

Gene Symbol IL13RA2
Uniprot