IL-12 R beta 2 Antibody (305719) [Alexa Fluor® 488]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 12 (IL-12), the founding member of the IL-12 family of heterodimeric cytokines, is composed of two disulfide-linked 35 kDa and 40 kDa subunits. The 35 kDa subunit (p35) is a alpha -helical protein homologous to IL-6 and G-CSF. The 40 kDa subunit (p40) contains one fibronectin type III and one Ig C2-like domain, and has a high degree of structural homology to type I cytokine receptors. Whereas p35 subunit is unique to IL-12, the p40 subunit is also a subunit of IL-23. IL-12 is an essential mediator of cellular-immunity that induces T cells and natural-killer cells to produce IFN-gamma . It is also required for the expansion and activation Th1 cells (1, 2).

The biological activities of IL-12 are mediated through the high-affinity receptor complex composed of the IL-12 Receptor beta 1 (IL-12 R beta 1) and IL-12 Receptor beta 2 (IL‑12 R beta 2) subunits. IL-12 R beta 1 is a 100 kDa protein that is also a subunit of the IL-23 receptor complex. It binds IL-12/IL-23 p40 and is associated with Tyk2. IL‑12 R beta 2 is a 130 kDa protein that interacts with p35 and is associated with Jak2. Both receptor subunits are type I membrane proteins that share similarities with the gp130/G-CSF R subgroup in the cytokine receptor superfamily. IL-12 R beta 2 cDNA encodes a 862 amino acid (aa) protein with a putative 27 aa signal peptide that is cleaved to generate the mature protein with a 595 aa extracellular domain, a 24 aa transmembrane domain and a 216 aa cytoplasmic region. Human and mouse IL‑12 R beta 2 share 68% amino acid sequence identity. Whereas IL-12 R beta 1 expression has been detected in activated T cells, NK cells and B cells, the expression of IL‑12 R beta 2 is more restricted. Among T cells, IL-12 R beta 2 is absent on naive T cells. Activation of T cells via TCR up‑regulates IL‑12 R beta 2 expression on human Th1 but not Th2 cells (1‑4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 5 of 5.

Publications using FAB1959G	Applications	Species
Cohn, IS;Wallbank, BA;Haskins, BE;O'Dea, KM;Pardy, RD;Shaw, S;Merolle, MI;Gullicksrud, JA;Christian, DA;Striepen, B;Hunter, CA; Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4 + T cell-mediated resistance to Cryptosporidium bioRxiv : the preprint server for biology 2023-11-13 [PMID: 38014026] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
JD Coakley, EP Breen, A Moreno-Oli, AI Al-Harbi, AM Melo, B O'Connell, R McManus, DG Doherty, T Ryan Innate Lymphocyte Th1 and Th17 Responses in Elderly Hospitalised Patients with Infection and Sepsis Vaccines (Basel), 2020-06-17;8(2):. 2020-06-17 [PMID: 32560376] (Flow Cytometry, Human)	Flow Cytometry	Human
R Sun, C Abraham IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant Cell Mol Gastroenterol Hepatol, 2020-05-29;0(0):. 2020-05-29 [PMID: 32474165] (Flow Cytometry, Human)	Flow Cytometry	Human
Melissa M. Berrien-Elliott, Yaping Sun, Carly Neal, Aaron Ireland, Maria C. Trissal, Ryan P. Sullivan et al. MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells Immunity 9/1/2019 [PMID: 31402259]
K Kachler, M Bailer, L Heim, F Schumacher, M Reichel, C Holzinger, S Trump, S Mittler, J Monti, DI Trufa, RJ Rieker, A Hartmann, H Sirbu, B Kleuser, J Kornhuber, S Finotto Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma Cancer Res., 2017-09-07;0(0):. 2017-09-07 [PMID: 28883000] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array FAB1959G

• IL-12 R beta 2 Antibodies
• IL-12 R beta 2 ELISA Kits
• IL-12 R beta 2 Lysate
• IL-12 R beta 2 Proteins and Enzymes