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IFN-gamma R1/CD119 Antibody (92101) [Phycoerythrin]

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Human peripheral blood monocytes were stained with Mouse Anti-Human IFN-gamma R1/CD119 PE-conjugated Monoclonal Antibody (Catalog # FAB673P, filled histogram) or isotype control antibody (Catalog # IC002P, open ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
92101
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

Order Details

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IFN-gamma R1/CD119 Antibody (92101) [Phycoerythrin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IFN-gamma  R1
Glu18-Gly245
Accession # P15260.1
Specificity
Detects human IFN-gamma R1 in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant mouse IFN‑ gamma  R1, recombinant human (rh) IFN-gamma R2, or rhIL-10 R beta .
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IFNGR1
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Reviewed Applications
Read 1 Review rated 4
using
FAB673P in the following application:

Publications
Read Publications using
FAB673P in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-gamma R1/CD119 Antibody (92101) [Phycoerythrin]

  • AVP, type 2
  • CD119 antigen
  • CD119
  • FLJ45734
  • IFN-gamma R1
  • IFN-gamma receptor 1
  • IFNgammaR1
  • IFN-gamma-R1
  • IFNGR
  • IFNGR1
  • IFN-gR1
  • immune interferon receptor 1
  • interferon gamma receptor 1
  • interferon-gamma receptor alpha chain
  • type 2

Background

The high-affinity IFN-gamma  receptor complex is made up of two type I transmembrane proteins, IFN-gamma  R1 (IFN-gamma  R alpha ) and IFN-gamma  R2 (IFN-gamma  R beta ). Both proteins are members of the type II cytokine receptor family and share approximately 52% amino acid sequence identity. IFN-gamma  R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma  R2 is required for IFN-gamma signaling but does not bind IFN-gamma by itself. Human IFN-gamma  R1 cDNA encodes a 489 amino acid (aa) residue protein with a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Human and mouse IFN-gamma  R1 share 52% amino acid sequence identity and bind IFN-gamma in a species-specific manner. IFN-gamma  R1 is constitutively expressed in most cell types. Soluble IFN-gamma  R1 that binds IFN-gamma has been detected in biological fluids.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IFN-gamma R1/CD119 Antibody (FAB673P)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.


Filter By Application
Flow Cytometry
(4)
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Filter By Species
Human
(4)
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Showing Publications 1 - 5 of 5.
Publications using FAB673P Applications Species
Aiko Hirayama, Kentaro Tanaka, Hirono Tsutsumi, Takayuki Nakanishi, Sho Yamashita, Shun Mizusaki et al. Regulation of PD-L1 expression in non–small cell lung cancer by interleukin-1 beta Frontiers in Immunology 6/27/2023 [PMID: 37441079]
P Voabil, M de Bruijn, LM Roelofsen, SH Hendriks, S Brokamp, M van den Br, A Broeks, J Sanders, P Herzig, A Zippelius, CU Blank, KJ Hartemink, K Monkhorst, JBAG Haanen, TN Schumacher, DS Thommen An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer Nature Medicine, 2021-07-08;27(7):1250-1261. 2021-07-08 [PMID: 34239134] (Flow Cytometry, Human) Flow Cytometry Human
C Lundtoft, P Pucholt, J Imgenberg-, J Carlsson-A, ML Eloranta, AC Syvänen, G Nordmark, JK Sandling, I Kockum, T Olsson, L Rönnblom, N Hagberg Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling PLoS Genet, 2020-10-26;16(10):e1009199. 2020-10-26 [PMID: 33104735] (Flow Cytometry, Human) Flow Cytometry Human
P López, J Rodríguez-, A Martínez-Z, L Caminal-Mo, A Suárez Circulating microparticle subpopulations in systemic lupus erythematosus are affected by disease activity Int. J. Cardiol, 2017-03-01;0(0):. 2017-03-01 [PMID: 28279502] (Flow Cytometry, Human) Flow Cytometry Human
Ghirelli C, Zollinger R, Soumelis V Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells. Blood, 2010-04-09;115(24):5037-40. 2010-04-09 [PMID: 20382843] (Flow Cytometry, Human) Flow Cytometry Human

Review for IFN-gamma R1/CD119 Antibody (FAB673P) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using FAB673P:
Filter by Applications
Flow
(1)
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Filter by Species
Mouse
(1)
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Images Ratings Applications Species Date Details
  4
reviewed by:
Verified Customer
Flow Mouse 01/27/2015
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Summary

ApplicationFlow Cytometry
Sample TestedSee PMID: 23089549
SpeciesMouse

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Recent Reviews

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5
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Verified Customer
01/27/2015
Application: Flow
Species: Mouse

Bioinformatics

Gene Symbol IFNGR1
Uniprot