IFN-gamma R1/CD119 Products

Description

IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains.

Bioinformatics

Entrez	15978 Mouse 15979 Mouse 25712 Rat 3459 Human
Uniprot	AAH05333.1 Human NM_000416 Human P15260 Human
Product By Gene ID	3459
Alternate Names	AVP, type 2 CD119 antigen CD119 FLJ45734 IFN-gamma receptor 1 IFN-gamma-R1 IFNGR immune interferon receptor 1 interferon gamma receptor 1 interferon-gamma receptor alpha chain type 2

Research Areas for IFN-gamma R1/CD119

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology
Innate Immunity
Neuroscience