IFN-gamma Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature rat IFN-gamma exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). It shares 86% amino acid sequence identity with mouse IFN-gamma and 37-45% with bovine, canine, cotton rat, equine, feline, human, porcine, and rhesus macaque IFN-gamma . IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: IHC-Fr, Neutralization.

Showing Publications 1 - 8 of 8.

Publications using AF-585-NA	Applications	Species
Ronja Mathiesen, Helene M. S. Eld, Juliane Sørensen, Eva Fuglsang, Lisbeth Drozd Lund, Valentina Taverniti et al. Mannan Enhances IL-12 Production by Increasing Bacterial Uptake and Endosomal Degradation in L. acidophilus and S. aureus Stimulated Dendritic Cells Frontiers in Immunology 11/15/2019 [PMID: 31803184]
M Dang, X Zeng, B Chen, H Wang, H Li, F Du, C Guo Interferon-? mediates the protective effects of soluble receptor for advanced glycation end-product in myocardial ischemia/reperfusion Lab. Invest., 2018-08-08;0(0):. 8/8/2018 [PMID: 30089851]
Xinwei Feng, Junfeng Lu, Zitian He, Yidan Wang, Fangfang Qi, Rongbiao Pi et al. Mycobacterium smegmatis Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells Frontiers in Cellular and Infection Microbiology 6/19/2018 [PMID: 29988402]
Jin Wang, Tongxin Xie, Bingbing Wang, William N. William, John V. Heymach, Adel K. El-Naggar et al. PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions Cancer Prevention Research 12/1/2017 [PMID: 29018057]
XH Chen, LL Zheng Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus Mol Med Rep, 2017-08-11;0(0):. 2017-08-11 [PMID: 28849125]
VE Thaney, AM O'Neill, MM Hoefer, R Maung, AB Sanchez, M Kaul IFN? Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury Sci Rep, 2017-04-20;7(0):46514. 2017-04-20 [PMID: 28425451] (Neutralization, Mouse, Rat)	Neutralization	Mouse, Rat
Shigemoto-Mogami Y, Hoshikawa K, Goldman J, Sekino Y, Sato K Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone. J Neurosci, 2014-02-05;34(6):2231-43. 2014-02-05 [PMID: 24501362] (Neutralization, Rat)	Neutralization	Rat
Rana S, Byrne SN, MacDonald LJ, Chan CY, Halliday GM Ultraviolet B suppresses immunity by inhibiting effector and memory T cells. Am. J. Pathol., 2008-02-21;172(4):993-1004. 2008-02-21 [PMID: 18292235] (IHC-Fr, Mouse)	IHC-Fr	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-P	Mouse	08/21/2017	View Summary Application Immunohistochemistry-Paraffin Sample Tested Mouse oral tumor cells Species Mouse Lot AHX0817011

Array AF-585-NA

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes