IFN-beta Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ELISA Capture, ELISA Development, ELISA Development (Detection).

Showing Publications 1 - 10 of 10.

Publications using 32400-1	Applications	Species
Magri, Z;Jetton, D;Muendlein, HI;Connolly, WM;Russell, H;Smirnova, I;Sharma, S;Bunnell, S;Poltorak, A; CD14 is a decision-maker between Fas-mediated death and inflammation Cell reports 2024-08-29 [PMID: 39213151] (ELISA Capture, Mouse)	ELISA Capture	Mouse
Hayley I. Muendlein, Wilson M. Connolly, James Cameron, David Jetton, Zoie Magri, Irina Smirnova et al. Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses Science Immunology 12/23/2022 [PMID: 36563168]
HI Muendlein, WM Connolly, Z Magri, D Jetton, I Smirnova, A Degterev, S Balachandr, A Poltorak ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF Proceedings of the National Academy of Sciences of the United States of America, 2022-06-06;119(24):e2113872119. 2022-06-06 [PMID: 35666872] (ELISA Capture, Mouse)	ELISA Capture	Mouse
Brandon M. Johnson, Toru Uchimura, Matthew D. Gallovic, Madhan Thamilarasan, Wei-Chun Chou, Sara A. Gibson et al. STING Agonist Mitigates Experimental Autoimmune Encephalomyelitis by Stimulating Type I IFN–Dependent and –Independent Immune-Regulatory Pathways The Journal of Immunology 5/1/2021 [PMID: 33820855]
Chunmei Ma, Sheng Li, Yingchao Hu, Yan Ma, Yuqing Wu, Chunyan Wu et al. AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis Journal of Experimental Medicine 5/3/2021 [PMID: 33710283]
Caitlyn T. Hoffpauir, Samantha L. Bell, Kelsi O. West, Tao Jing, Allison R. Wagner, Sylvia Torres-Odio et al. TRIM14 is a key regulator of the type I interferon response during Mycobacterium tuberculosis infection The Journal of Immunology 7/1/2020 [PMID: 32404352]
Tianliang Li, Xinghui Li, Kuldeep S. Attri, Changhong Liu, Lupeng Li, Laura E. Herring et al. O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity Cell Host & Microbe 12/1/2018 [PMID: 30543776]
BC Liu, J Sarhan, A Panda, HI Muendlein, V Ilyukha, J Coers, M Yamamoto, RR Isberg, A Poltorak Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses Cell Rep, 2018-07-03;24(1):155-168.e5. 2018-07-03 [PMID: 29972777] (ELISA Development (Detection), Human, Mouse)	ELISA Development (Detection)	Human, Mouse
Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA Evaluating vaccinia virus cytokine co-expression in TLR GKO mice. Immunol. Cell Biol., 2010-12-21;89(0):706-15. 2010-12-21 [PMID: 21173782] (ELISA Development, Mouse)	ELISA Development	Mouse
Joshi VD, Kalvakolanu DV, Chen W, Zhang L, Kang TJ, Thomas KE, Vogel SN, Cross AS A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression. J. Interferon Cytokine Res., 2006-10-01;26(10):739-47. 2006-10-01 [PMID: 17032168] (ELISA Development, Mouse)	ELISA Development	Mouse

Array 32400-1

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta Proteins and Enzymes
• IFN-beta ELISAs