Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human TGF-beta RIII DuoSet ELISA, 15 Plate
betaglycan proteoglycan
Betaglycan
BGCAN
TBRIII
TGF-beta receptor type 3
TGF-beta receptor type III
TGF-beta RIII
TGFbetaRIII
TGFBR3
TGF-bRIII
TGFR-3
Transforming growth factor beta receptor III
transforming growth factor beta receptor type 3
transforming growth factor, beta receptor III (betaglycan, 300kDa)
transforming growth factor, beta receptor III
Background
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.