Human M-CSF DuoSet ELISA, 15 Plate

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M-CSF, also known as CSF-1, is a four-alpha-helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis. M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells. The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen. Shorter transcripts encode M-CSF that lack cleavage and PG sites and produce an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer. Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor. The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using DY216	Applications	Species
Reina, J;Vallmajo-Martin, Q;Ning, J;Michi, AN;Yeung, K;Wahl, GM;Hunter, T; LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment bioRxiv : the preprint server for biology 2024-04-23 [PMID: 38712081] (Human)		Human
Surve, CR;Duran, CL;Ye, X;Chen, X;Lin, Y;Harney, AS;Wang, Y;Sharma, VP;Stanley, ER;McAuliffe, JC;Entenberg, D;Oktay, MH;Condeelis, JS; Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination bioRxiv : the preprint server for biology 2024-01-09 [PMID: 38260319] (Mouse)		Mouse
Michielon, E;López González, M;Stolk, DA;Stolwijk, JGC;Roffel, S;Waaijman, T;Lougheed, SM;de Gruijl, TD;Gibbs, S; A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion Cancers 2023-05-20 [PMID: 37345186] (Human)		Human
DY Achkova, RE Beatson, J Maher CAR T-Cell Targeting of Macrophage Colony-Stimulating Factor Receptor Cells, 2022-07-13;11(14):. 2022-07-13 [PMID: 35883636] (Human)		Human
KN Lee, KH Park, YM Kim, I Cho, TE Kim Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid PLoS ONE, 2022-05-10;17(5):e0268291. 2022-05-10 [PMID: 35536791] (Human)		Human
S Hakki, EJ Robinson, MG Robson Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula Scientific Reports, 2022-01-26;12(1):1427. 2022-01-26 [PMID: 35082332] (Human)		Human
Y Jung, M Son, YR Nam, J Choi, JR Heath, S Yang Microfluidic Single-Cell Proteomics Assay Chip: Lung Cancer Cell Line Case Study Micromachines, 2021-09-23;12(10):. 2021-09-23 [PMID: 34683198] (Human)		Human
IJ Yeh, SC Chen, MC Yen, YH Wu, CH Hung, PL Kuo 6-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential Nutrients, 2019-09-28;11(10):. 2019-09-28 [PMID: 31569368] (Human)		Human
YJ Park, SJ Woo, YM Kim, S Hong, YE Lee, KH Park Immune and Inflammatory Proteins in Cord Blood as Predictive Biomarkers of Retinopathy of Prematurity in Preterm Infants Invest. Ophthalmol. Vis. Sci., 2019-09-03;60(12):3813-3820. 2019-09-03 [PMID: 31525777] (Human)		Human
P Dimou, RD Wright, KL Budge, A Midgley, SC Satchell, M Peak, MW Beresford The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis Sci Rep, 2019-06-06;9(1):8348. 2019-06-06 [PMID: 31171837] (Human)		Human
F Hua, Y Tian, Y Gao, C Li, X Liu Colony?stimulating factor 1 receptor inhibition blocks macrophage infiltration and endometrial cancer cell proliferation Mol Med Rep, 2019-02-18;0(0):. 2019-02-18 [PMID: 30816518] (Human)		Human
O Giricz, Y Mo, KB Dahlman, XM Cotto-Rios, C Vardabasso, H Nguyen, B Matusow, M Bartenstei, V Polishchuk, DB Johnson, TD Bhagat, R Shellooe, E Burton, J Tsai, C Zhang, G Habets, JM Greally, Y Yu, PA Kenny, GB Fields, K Pradhan, ER Stanley, E Bernstein, G Bollag, E Gavathioti, BL West, JA Sosman, AK Verma The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma JCI Insight, 2018-07-26;3(14):. 2018-07-26 [PMID: 30046005] (Human)		Human
E Ribechini, JA Hutchinson, S Hergovits, M Heuer, J Lucas, U Schleicher, AL Jordán Gar, SJ Potter, P Riquelme, H Brackmann, N Müller, H Raifer, I Berberich, M Huber, A Beilhack, M Lohoff, C Bogdan, M Eyrich, HM Hermanns, EK Geissler, MB Lutz Novel GM-CSF signals via IFN-?R/IRF-1 and AKT/mTOR license monocytes for suppressor function Blood Adv, 2017-06-07;1(14):947-960. 2017-06-07 [PMID: 29296736] (Human)		Human
Nijaguna M, Patil V, Urbach S, Shwetha S, Sravani K, Hegde A, Chandramouli B, Arivazhagan A, Marin P, Santosh V, Somasundaram K Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis. J Biol Chem, 2015-08-05;290(38):23401-15. 2015-08-05 [PMID: 26245897] (Human)		Human
Cheng K, Wong S, Linn Y, Ho L, Chng W, Schwarz H CD137 ligand signalling induces differentiation of primary acute myeloid leukaemia cells. Br J Haematol, 2014-01-15;165(1):134-44. 2014-01-15 [PMID: 24428589] (Human)		Human
Lamprecht B, Walter K, Kreher S, Kumar R, Hummel M, Lenze D, Kochert K, Bouhlel MA, Richter J, Soler E, Stadhouders R, Johrens K, Wurster KD, Callen DF, Harte MF, Giefing M, Barlow R, Stein H, Anagnostopoulos I, Janz M, Cockerill PN, Siebert R, Dorken B, Bonifer C, Mathas S Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat. Med., 2010-05-02;16(5):571-9. 2010-05-02 [PMID: 20436485] (Human)		Human
Chang YC, Chen TC, Lee CT, Yang CY, Wang HW, Wang CC, Hsieh SL Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. Blood, 2008-03-18;111(10):5054-63. 2008-03-18 [PMID: 18349319] (Human)		Human
Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood, 2007-09-11;110(13):4319-30. 2007-09-11 [PMID: 17848619] (Human)		Human
Merck E, Gaillard C, Scuiller M, Scapini P, Cassatella MA, Trinchieri G, Bates EE Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils. J. Immunol., 2006-03-01;176(5):3149-56. 2006-03-01 [PMID: 16493074] (Human)		Human
Show All 19 Publications. Collapse Publications.

Array DY216

• M-CSF Antibodies
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• M-CSF Proteins
• M-CSF ELISAs
• M-CSF Proteins and Enzymes