Human IGFBP-2 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Immunohistochemistry.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using DY674	Applications	Species
Aline Schmoll, K;Mager, T;Tse, TP;Alameldeen, A;Zimmermann, WH;Zafeiriou, MP; Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line Stem cell research 2024-01-28 [PMID: 38295750] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Mester, P;Räth, U;Schmid, S;Amend, P;Keller, D;Krautbauer, S;Bondarenko, S;Müller, M;Buechler, C;Pavel, V; Serum Insulin-like Growth Factor-Binding Protein-2 as a Prognostic Factor for COVID-19 Severity Biomedicines 2024-01-08 [PMID: 38255230] (Human)		Human
J Kletzer, S Hecht, S Ramsauer, B Scharinger, R Kaufmann, J Kammler, J Kellermair, K Akbari, H Blessberge, C Steinwende, K Hergan, UC Hoppe, M Lichtenaue, E Boxhammer A Story of PA/BSA and Biomarkers to Diagnose Pulmonary Hypertension in Patients with Severe Aortic Valve Stenosis-The Rise of IGF-BP2 and GDF-15 Journal of cardiovascular development and disease, 2023-01-05;10(1):. 2023-01-05 [PMID: 36661917] (Human)		Human
S Hecht, E Boxhammer, R Kaufmann, B Scharinger, C Reiter, J Kammler, J Kellermair, M Hammerer, H Blessberge, C Steinwende, UC Hoppe, K Hergan, M Lichtenaue CT-Diagnosed Sarcopenia and Cardiovascular Biomarkers in Patients Undergoing Transcatheter Aortic Valve Replacement: Is It Possible to Predict Muscle Loss Based on Laboratory Tests?-A Multicentric Retrospective Analysis Journal of personalized medicine, 2022-09-04;12(9):. 2022-09-04 [PMID: 36143238] (Human)		Human
S Hong, KH Park, YE Lee, JE Lee, YM Kim, E Joo, I Cho Antibody microarray analysis of amniotic fluid proteomes in women with cervical insufficiency and short cervix, and their association with pregnancy latency length PLoS ONE, 2022-02-07;17(2):e0263586. 2022-02-07 [PMID: 35130326] (Human)		Human
A Ozen, N Kasap, I Vujkovic-C, R Apps, F Cheung, E Karakoc-Ay, B Akkelle, S Sari, E Tutar, F Ozcay, DK Uygun, A Islek, G Akgun, M Selcuk, OB Sezer, Y Zhang, G Kutluk, E Topal, E Sayar, C Celikel, RHJ Houwen, A Bingol, I Ogulur, SB Eltan, AL Snow, C Lake, G Fantoni, C Alba, B Sellers, SD Chauvin, CL Dalgard, O Harari, YG Ni, MD Wang, K Devalaraja, P Subramania, R Ergelen, R Artan, SN Guner, B Dalgic, J Tsang, Y Belkaid, D Ertem, S Baris, MJ Lenardo Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease Nature Immunology, 2021-01-04;0(0):. 2021-01-04 [PMID: 33398182] (Human)		Human
YJ Park, SJ Woo, YM Kim, S Hong, YE Lee, KH Park Immune and Inflammatory Proteins in Cord Blood as Predictive Biomarkers of Retinopathy of Prematurity in Preterm Infants Invest. Ophthalmol. Vis. Sci., 2019-09-03;60(12):3813-3820. 2019-09-03 [PMID: 31525777] (Human)		Human
Y Liu, F Li, YT Yang, XD Xu, JS Chen, TL Chen, HJ Chen, YB Zhu, JY Lin, Y Li, XM Xie, XL Sun, YQ Ke IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma Oncogene, 2018-10-27;0(0):. 2018-10-27 [PMID: 30368528] (Human)		Human
Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro Oncotarget, 2016-05-31;7(22):32129-43. 2016-05-31 [PMID: 27050076] (Human)		Human
CC Mok, HH Ding, M Kharboutli, C Mohan Axl, Ferritin, Insulin-Like Growth Factor Binding Protein 2, and Tumor Necrosis Factor Receptor Type II as Biomarkers in Systemic Lupus Erythematosus Arthritis Care Res (Hoboken), 2016-07-28;68(9):1303-9. 2016-07-28 [PMID: 26749069] (Human)		Human
Yau S, Russo V, Clarke I, Dunshea F, Werther G, Sabin M IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes. Int J Obes (Lond), 2014-11-05;39(5):770-81. 2014-11-05 [PMID: 25370576] (Human)		Human
Migita T, Narita T, Asaka R, Miyagi E, Nagano H, Nomura K, Matsuura M, Satoh Y, Okumura S, Nakagawa K, Seimiya H, Ishikawa Y Role of insulin-like growth factor binding protein 2 in lung adenocarcinoma: IGF-independent antiapoptotic effect via caspase-3. Am. J. Pathol., 2010-02-11;176(4):1756-66. 2010-02-11 [PMID: 20150439] (Human)		Human
Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009-11-19;4(11):e7916. 2009-11-19 [PMID: 19936259] (Human)		Human
Eiseman JL, Guo J, Ramanathan RK, Belani CP, Solit DB, Scher HI, Ivy SP, Zuhowski EG, Egorin MJ Evaluation of plasma insulin-like growth factor binding protein 2 and Her-2 extracellular domain as biomarkers for 17-allylamino-17-demethoxygeldanamycin treatment of adult patients with advanced solid tumors. Clin. Cancer Res., 2007-04-01;13(7):2121-7. 2007-04-01 [PMID: 17404095] (Human)		Human
Show All 14 Publications. Collapse Publications.

Array DY674

• IGFBP-2 Antibodies
• IGFBP-2 ELISA Kits
• IGFBP-2 Protein
• IGFBP-2 ELISAs
• IGFBP-2 Proteins and Enzymes