Human IFN-beta ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 31. Show All 31 Publications. Collapse Publications.

Publications using 41410-1	Applications	Species
Ferecsk�, AS;Smallwood, MJ;Moore, A;Liddle, C;Newcombe, J;Holley, J;Whatmore, J;Gutowski, NJ;Eggleton, P; STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases Biomedicines 2023-05-05 [PMID: 37239045] (Human)		Human
X Kong, X Lu, S Wang, J Hao, D Guo, H Wu, Y Jiang, Y Sun, J Wang, G Zhang, Z Cai Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner Cell Reports, 2023-01-19;42(1):112002. 2023-01-19 [PMID: 36662617] (Mouse)		Mouse
RS Singh, V Vidhyasaga, S Yang, AB Arna, M Yadav, A Aggarwal, AN Aguilera, S Shinriki, KK Bhanumathy, K Pandey, A Xu, N Rapin, M Bosch, J DeCoteau, J Xiang, FJ Vizeacouma, Y Zhou, V Misra, H Matsui, SR Ross, Y Wu DDX41 is required for cGAS-STING activation against DNA virus infection Cell Reports, 2022-05-24;39(8):110856. 2022-05-24 [PMID: 35613581] (Human)		Human
J Wu, Y Shi, X Pan, S Wu, R Hou, Y Zhang, T Zhong, H Tang, W Du, L Wang, J Wo, J Mu, Y Qiu, K Yang, LK Zhang, BC Ye, N Qi SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO Cell Reports, 2021-02-03;34(7):108761. 2021-02-03 [PMID: 33567255] (Human)		Human
S Ding, J Diep, N Feng, L Ren, B Li, YS Ooi, X Wang, KF Brulois, LL Yasukawa, X Li, CJ Kuo, DA Solomon, JE Carette, HB Greenberg STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection Nat Commun, 2018-04-16;9(1):1485. 2018-04-16 [PMID: 29662124] (Human)		Human
M Bugge, B Bergstrom, OK Eide, H Solli, IF Kjønstad, J Stenvik, T Espevik, NJ Nilsen Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Inflammatory Cytokine Production and Promotes Invasiveness J. Biol. Chem., 2017-07-17;0(0):. 2017-07-17 [PMID: 28717003] (Human)		Human
Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production Proc Natl Acad Sci USA, 2016-09-06;113(38):10625-10630. 2016-09-06 [PMID: 27601648] (Human)		Human
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5 PLoS ONE, 2016-08-09;11(8):e0160875. 2016-08-09 [PMID: 27504984] (Human)		Human
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection PLoS Pathog, 2016-07-28;12(7):e1005770. 2016-07-28 [PMID: 27467705] (Mouse)		Mouse
M Tatematsu, R Yoshida, Y Morioka, N Ishii, K Funami, A Watanabe, K Saeki, T Seya, M Matsumoto Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner J Immunol, 2016-03-28;0(0):. 2016-03-28 [PMID: 27022195] (Human)		Human
Villenave R, Broadbent L, Douglas I, Lyons J, Coyle P, Teng M, Tripp R, Heaney L, Shields M, Power U Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium. J Virol, 2015-09-30;89(24):12309-18. 2015-09-30 [PMID: 26423940] (Human)		Human
Hosein A, Livingstone J, Buchanan M, Reid J, Hallett M, Basik M A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer. BMC Cancer, 2015-03-15;15(0):130. 2015-03-15 [PMID: 25884794] (Human)		Human
Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus. J Virol, 2015-01-21;89(7):3859-69. 2015-01-21 [PMID: 25609809] (Human)		Human
Wu Z, Sinzger C, Reichel J, Just M, Mertens T Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responses. J Virol, 2014-12-24;89(5):2906-17. 2014-12-24 [PMID: 25540381] (Human)		Human
Ranjan P, Singh N, Kumar A, Neerincx A, Kremmer E, Cao W, Davis W, Katz J, Gangappa S, Lin R, Kufer T, Sambhara S NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection. Eur J Immunol, 2014-12-23;45(3):758-72. 2014-12-23 [PMID: 25404059] (Human)		Human
Zhang Y, Yeruva L, Marinov A, Prantner D, Wyrick P, Lupashin V, Nagarajan U The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-beta during Chlamydia trachomatis infection. J Immunol, 2014-07-28;193(5):2394-404. 2014-07-28 [PMID: 25070851] (Human)		Human
Liu H, Chen K, Feng W, Guo J, Li H HSV-2 increases TLR4-dependent phosphorylated IRFs and IFN-beta induction in cervical epithelial cells. PLoS ONE, 2014-04-10;9(4):e94806. 2014-04-10 [PMID: 24722640] (Human)		Human
Xia , Mao, Gonzalez , Patrick, Li , Chunyan, Meng , Gang, Jiang , Aiqin, Wang , Hongwei, Gao , Qian, Debatin , Klaus-Mi, Beltinger , Christia, Wei , Jiwu Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J Virol, 2014-02-26;88(9):5152-64. 2014-02-26 [PMID: 24574393] (Human)		Human
Stone , Amy E L, Giugliano , Silvia, Schnell , Gretja, Cheng , Linling, Leahy , Katelyn, Golden-Mason , Lucy, Gale , Michael, Rosen , Hugo R Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog, 2013-04-18;9(4):e1003316. 2013-04-18 [PMID: 23637605] (Human)		Human
Osterlund P, Strengell M, Sarin L, Poranen M, Fagerlund R, Melen K, Julkunen I Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry. J Virol, 2012;86(20):11183-93. 2012 [PMID: 22855501] (Human)		Human
Patel MV, Ghosh M, Fahey JV, Wira CR Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol. PLoS ONE, 2012-04-25;7(4):e35654. 2012-04-25 [PMID: 22558189] (Human)		Human
Wang P, Arjona A, Zhang Y Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat. Immunol., 2010-09-05;11(10):912-9. 2010-09-05 [PMID: 20818395] (Mouse)		Mouse
Liang X, Moseman EA, Farrar MA Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood, 2010-03-25;115(24):5041-52. 2010-03-25 [PMID: 20339095] (Human)		Human
Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. J. Allergy Clin. Immunol., 2009-06-27;124(2):260-9, 269.e1. 2009-06-27 [PMID: 19541356] (Human)		Human
Schirmer SH, van Royen N, Moerland PD, Fledderus JO, Henriques JP, van der Schaaf RJ, Vis MM, Baan J, Koch KT, Horrevoets AJ, Hoefer IE, Piek JJ Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans. J. Am. Coll. Cardiol., 2009-06-09;53(23):2141-7. 2009-06-09 [PMID: 19497439] (Human)		Human
Lee SH, Kim JS, Jun HK The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3. J. Immunol., 2009-05-01;182(9):5823-35. 2009-05-01 [PMID: 19380831] (Human)		Human
Chase JC, Celli J, Bosio CM Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4. Infect. Immun., 2008-11-03;77(1):180-95. 2008-11-03 [PMID: 18981246] (Human)		Human
Newcomb DC, Sajjan US, Nagarkar DR, Goldsmith AM, Bentley JK, Hershenson MB Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-07-13;293(4):L1021-8. 2007-07-13 [PMID: 17631613] (Human)		Human
Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling. Clin. Exp. Immunol., 2007-01-01;147(1):71-80. 2007-01-01 [PMID: 17177965] (Human)		Human
Emori Y, Ikeda T, Ohashi T, Masuda T, Kurimoto T, Takei M, Kannagi M Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages. J. Gen. Virol., 2004-09-01;85(0):2603-13. 2004-09-01 [PMID: 15302954] (Human)		Human
Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, Wang F, Godowski PJ APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J. Immunol., 2004-01-01;172(1):138-43. 2004-01-01 [PMID: 14688319] (Human)		Human
Show All 31 Publications. Collapse Publications.

Array 41410-1

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta Proteins and Enzymes
• IFN-beta ELISAs