Human CX3CL1/Fractalkine DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CX3CL1/Fractalkine is a transmembrane adhesion protein with a chemokine domain separated from the membrane by a mucin stalk. It is upregulated on many cell types during inflammation. The chemokine and mucin regions can be shed as a soluble chemokine that signals through the receptor CX3CR1. During extravasation, membrane-bound CX3CL1 traps leukocytes, then is cleaved to allow diapedesis. Soluble CX3CL1 protects neurons from microglial neurotoxicity, recruits macrophages for wound healing, recruits osteoclast precursors for bone resorption, and contributes to pathogenesis in coronary artery disease.

We have publications tested in 2 confirmed species: Human, Xenograft.

Showing Publications 1 - 10 of 25. Show All 25 Publications. Collapse Publications.

Publications using DY365	Applications	Species
Fiorillo, A;Gallego, JJ;Casanova-Ferrer, F;Giménez-Garzó, C;Urios, A;Ballester, MP;Durbán, L;Rios, MP;Megías, J;San Miguel, T;Kosenko, E;Escudero-García, D;Benlloch, S;Felipo, V;Montoliu, C; Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease International journal of molecular sciences 2023-06-20 [PMID: 37373554] (Human)		Human
Bruss, C;Kellner, K;Albert, V;Hutchinson, JA;Seitz, S;Ortmann, O;Brockhoff, G;Wege, AK; Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion Cancers 2023-05-04 [PMID: 37174080] (Human, Xenograft)		Human, Xenograft
AK Wege, TF Dreyer, A Teoman, O Ortmann, G Brockhoff, H Bronger CX3CL1 Overexpression Prevents the Formation of Lung Metastases in Trastuzumab-Treated MDA-MB-453-Based Humanized Tumor Mice (HTM) Cancers, 2021-05-18;13(10):. 2021-05-18 [PMID: 34070094] (Human, Xenograft)		Human, Xenograft
J Li, A Wuethrich, AAI Sina, HH Cheng, Y Wang, A Behren, PN Mainwaring, M Trau A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy Nature Communications, 2021-02-17;12(1):1087. 2021-02-17 [PMID: 33597530] (Human)		Human
E Yeregui, C Viladés, P Domingo, A Ceausu, YM Pacheco, S Veloso, A Inciarte, J Vidal-Gonz, M Peraire, C Perpiñán, V Falcó, J Masip, V Alba, M Vargas, A Martí, L Reverté, J Mallolas, F Vidal, J Peraire, A Rull High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients EBioMedicine, 2020-11-06;62(0):103077. 2020-11-06 [PMID: 33166788] (Human)		Human
S Ma, T Tominaga, K Kanda, K Sugama, C Omae, S Hashimoto, K Aoyama, Y Yoshikai, K Suzuki Effects of an 8-Week Protein Supplementation Regimen with Hyperimmunized Cow Milk on Exercise-Induced Organ Damage and Inflammation in Male Runners: A Randomized, Placebo Controlled, Cross-Over Study Biomedicines, 2020-03-04;8(3):. 2020-03-04 [PMID: 32143279] (Human)		Human
S Ishii, T Isozaki, H Furuya, H Takeuchi, Y Tsubokura, K Inagaki, T Kasama ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion Arthritis Res. Ther., 2018-08-02;20(1):159. 2018-08-02 [PMID: 30071898] (Human)		Human
Jesús Ávila Glycogen synthase kinase-3? regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease Cell. Mol. Life Sci., 2016-11-10;0(0):. 2016-11-10 [PMID: 27832289] (Human)		Human
Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, Rostene W, Baudouin C CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Mucosal Immunol, 2012-06-13;5(0):702. 2012-06-13 [PMID: 22692452] (Human)		Human
Suzuki F, Kubota T Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity. Arthritis Res. Ther., 2012-03-06;14(2):R48. 2012-03-06 [PMID: 22394569] (Human)		Human
Tole S, Durkan AM, Huang YW, Liu GY, Leung A, Jones LL, Taylor JA, Robinson LA Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion. Am. J. Physiol., Cell Physiol., 2010-03-17;298(6):C1469-80. 2010-03-17 [PMID: 20237149] (Human)		Human
Hurst LA, Bunning RA, Couraud PO, Romero IA, Weksler BB, Sharrack B, Woodroofe MN Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment. J. Neuroimmunol., 2009-03-25;210(1):108-12. 2009-03-25 [PMID: 19324423] (Human)		Human
Peng W, Chen J, Jiang Y, Wu J, Shou Z, He Q, Wang Y, Chen Y, Wang H Urinary fractalkine is a marker of acute rejection. Kidney Int., 2008-09-17;74(11):1454-60. 2008-09-17 [PMID: 18800027] (Human)		Human
Nevo I, Sagi-Assif O, Meshel T, Ben-Baruch A, Johrer K, Greil R, Trejo LE, Kharenko O, Feinmesser M, Yron I, Witz IP The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells. Cancer Lett., 2008-09-07;273(1):127-39. 2008-09-07 [PMID: 18778890] (Human)		Human
Husberg C, Nygard S, Finsen AV, Damas JK, Frigessi A, Oie E, Waehre A, Gullestad L, Aukrust P, Yndestad A, Christensen G Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure. J. Mol. Cell. Cardiol., 2008-05-28;45(2):261-9. 2008-05-28 [PMID: 18585734] (Human)		Human
Banerjee A, Damera G, Bhandare R, Gu S, Lopez-Boado Y, Panettieri R, Tliba O Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br. J. Pharmacol., 2008-06-16;155(1):84-92. 2008-06-16 [PMID: 18552877] (Human)		Human
Jamieson WL, Shimizu S, D'Ambrosio JA, Meucci O, Fatatis A CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res., 2008-03-15;68(6):1715-22. 2008-03-15 [PMID: 18339851] (Human)		Human
Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, van der Wal T, Luinge M, Alvarez-Llamas G, Vos H, Poppema S, Vonk R, Van Den Berg A Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes. Blood, 2007-12-10;111(4):2339-46. 2007-12-10 [PMID: 18070985] (Human)		Human
Bolovan-Fritts CA, Spector SA Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction. Blood, 2007-09-25;111(1):175-82. 2007-09-25 [PMID: 17895402] (Human)		Human
Bolovan-Fritts CA, Trout RN, Spector SA High T-cell response to human cytomegalovirus induces chemokine-mediated endothelial cell damage. Blood, 2007-05-22;110(6):1857-63. 2007-05-22 [PMID: 17519388] (Human)		Human
Faure V, Cerini C, Paul P, Berland Y, Dignat-George F, Brunet P The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro. Int. Immunol., 2006-09-05;18(10):1453-9. 2006-09-05 [PMID: 16954166] (Human)		Human
Sato E, Iikuni N, Yoshio T, Minota S, Kamatani N, Okamoto H Soluble fractalkine in the cerebrospinal fluid of patients with neuropsychiatric lupus. Ann. Rheum. Dis., 2006-09-01;65(9):1257-9. 2006-09-01 [PMID: 16905589] (Human)		Human
Isse K, Harada K, Zen Y, Kamihira T, Shimoda S, Harada M, Nakanuma Y Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology, 2005-03-01;41(3):506-16. 2005-03-01 [PMID: 15726664] (Human)		Human
Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, Freyssinet JM, Tardieu M Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur. J. Neurosci., 2004-12-01;20(12):3222-32. 2004-12-01 [PMID: 15610155] (Human)		Human
Bolovan-Fritts CA, Trout RN, Spector SA Human cytomegalovirus-specific CD4+-T-cell cytokine response induces fractalkine in endothelial cells. J. Virol., 2004-12-01;78(23):13173-81. 2004-12-01 [PMID: 15542669] (Human)		Human
Show All 25 Publications. Collapse Publications.

Array DY365

• CX3CL1/Fractalkine Antibodies
• CX3CL1/Fractalkine Antibody Pair
• CX3CL1/Fractalkine ELISA Kit
• CX3CL1/Fractalkine Proteins
• CX3CL1/Fractalkine ELISAs
• CX3CL1/Fractalkine Proteins and Enzymes