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Human CCL11/Eotaxin Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human CCL11/Eotaxin Quantikine ELISA Kit Summary

Background
The Quantikine Human Eotaxin Immunoassay is a 3.5 hour solid phase ELISA designed to measure human Eotaxin in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human Eotaxin and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human Eotaxin accurately. Results obtained measuring natural hu...man eotaxin showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human Eotaxin.
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Specificity
Natural and recombinant human Eotaxin
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CCL11

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DTX00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL11/Eotaxin Quantikine ELISA Kit

  • C-C motif chemokine 11
  • CCL11
  • chemokine (C-C motif) ligand 11
  • Eosinophil chemotactic protein
  • Eotaxin
  • eotaxin-1
  • MGC22554
  • SCYA11Small-inducible cytokine A11
  • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

Background

CCL11/Eotaxin is a chemokine that interacts with CCR3 to induce eosinophil, basophil, dendritic cell, and Th2 cell chemoattraction during inflammatory and allergic reactions. Its production is upregulated in airway epithelium, alveolar macrophages, eosinophils, smooth muscle cells, chondrocytes, and fibroblasts following allergen or inflammatory challenge. CCL11 is also involved in the growth of myeloid cell progenitors and the differentiation of mast cells.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL11/Eotaxin (DTX00)(34)

We have publications tested in 1 confirmed species: Human.


Filter By Application
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Human
(34)
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Showing Publications 1 - 10 of 34. Show All 34 Publications.
Publications using DTX00 Applications Species
S Zhang, D Dong, Y Zhang, J Wang, L Liu, Y Zhao miR-124-3p relieves allergic rhinitis by inhibiting dipeptidyl peptidase-4 International immunopharmacology, 2021-10-26;101(0):108279. 2021-10-26 [PMID: 34715574] (Human) Human
S Ravichandr, G Grubbs, J Tang, Y Lee, C Huang, H Golding, S Khurana Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2-infected individuals reveal unlinked immune signatures Science Advances, 2021-10-13;7(42):eabi6533. 2021-10-13 [PMID: 34644111] (Human) Human
G Scabia, G Testa, M Scali, S Del Turco, G Desiato, N Berardi, A Sale, M Matteoli, L Maffei, M Maffei, M Mainardi, “Train the Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus Brain, Behavior, and Immunity, 2021-08-19;98(0):234-244. 2021-08-19 [PMID: 34418501] (Human) Human
F Zhou, P Liu, H Lv, Z Gao, W Chang, Y Xu miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses Mol Med Rep, 2020-11-12;23(1):. 2020-11-12 [PMID: 33179116] (Human) Human
MW Han, SH Kim, I Oh, YH Kim, J Lee Serum IL-1 β can be a biomarker in children with severe persistent allergic rhinitis Allergy Asthma Clin Immunol, 2019-09-18;15(0):58. 2019-09-18 [PMID: 31548841] (Human) Human
L Butcher, K Pérès, P André, RH Morris, S Walter, JF Dartigues, L Rodriguez-, C Feart, JD Erusalimsk Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers Exp. Gerontol., 2018-10-09;113(0):173-179. 2018-10-09 [PMID: 30308289] (Human) Human
M Sun, Y Huang, F Li, H Li, B Zhang, L Jin MicroRNA-874 inhibits TNF-?-induced remodeling in human fetal airway smooth muscle cells by targeting STAT3 Respir Physiol Neurobiol, 2018-02-12;0(0):. 2018-02-12 [PMID: 29448029] (Human) Human
Cherry J, Stein T, Tripodis Y, Alvarez V, Huber B, Au R, Kiernan P, Daneshvar D, Mez J, Solomon T, Alosco M, McKee A CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. PLoS ONE, 2017-09-26;12(9):e0185541. 2017-09-26 [PMID: 28950005] (Human) Human
NA Johdi, L Mazlan, I Sagap, R Jamal Profiling of cytokines, chemokines and other soluble proteins as a potential biomarker in colorectal cancer and polyps Cytokine, 2017-07-06;99(0):35-42. 2017-07-06 [PMID: 28689023] (Human) Human
Bostrom E, Kindstedt E, Sulniute R, Palmqvist P, Majster M, Holm C, Zwicker S, Clark R, Onell S, Johansson I, Lerner U, Lundberg P Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines. PLoS ONE, 2015-08-04;10(8):e0134608. 2015-08-04 [PMID: 26241961] (Human) Human
Show All 34 Publications.

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Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation
By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...  Read full blog post.

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Bioinformatics

Gene Symbol CCL11