HSP60 Antibody (264233) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Heat shock proteins (HSPs) are a family of highly conserved stress response proteins. Heat shock proteins function primarily as molecular chaperones by facilitating the folding of other cellular proteins, preventing protein aggregation or targeting improperly folded proteins to specific degradative pathways. HSPs are typically expressed at low levels under normal physiological conditions but are dramatically upregulated in response to cellular stress. Heat Shock Protein 60 (HSP60), also known as Chaperonin 60 (CPN60), is a mitochondrial matrix protein belonging to a highly conserved family of molecular chaperone and stress response proteins. HSP60 plays a role in stabilizing and refolding proteins in response to heat-shock or other cellular stress. Full length human HSP60 is 98% identical to mouse and rat HSP60.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IHC-Fr, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using MAB1800	Applications	Species
KT Stein, SJ Moon, AN Nguyen, HD Sikes Kinetic modeling of H2O2 dynamics in the mitochondria of HeLa cells PLoS Comput. Biol., 2020-09-14;16(9):e1008202. 2020-09-14 [PMID: 32925922] (Western Blot, Human)	Western Blot	Human
SY Choi, R Lopez-Gonz, G Krishnan, HL Phillips, AN Li, WW Seeley, WD Yao, S Almeida, FB Gao C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo Nat. Neurosci., 2019-05-13;0(0):. 2019-05-13 [PMID: 31086314] (IHC-Fr, Mouse)	IHC-Fr	Mouse
J Wettmarsha, V Goh, KT Huang, DM Arduino, U Tripathi, A Leimpek, Y Cheng, AA Pittis, T Gabaldón, D Mokranjac, G Hajnóczky, F Perocchi MICU1 Confers Protection from MCU-Dependent Manganese Toxicity Cell Rep, 2018-11-06;25(6):1425-1435.e7. 2018-11-06 [PMID: 30403999] (Western Blot, Human)	Western Blot	Human
Guangxin Li Comparative analysis of the interaction of HSPs in dendritic cells, macrophages, RGM-1 cells infected by Helicobacter pylori Am J Transl Res, 2016-10-15;8(10):4184-4194. 2016-10-15 [PMID: 27830002] (Western Blot, Rat)	Western Blot	Rat
Noelker C, Morel L, Osterloh A, Alvarez-Fischer D, Lescot T, Breloer M, Gold M, Oertel W, Henze C, Michel P, Dodel R, Lu L, Hirsch E, Hunot S, Hartmann A Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease. J Neuroinflammation, 2014-05-08;11(0):86. 2014-05-08 [PMID: 24886419] (Western Blot, Human)	Western Blot	Human
Jing Ji, Yulia Y. Tyurina, Minke Tang, Weihong Feng, Donna B. Stolz, Robert S.B. Clark et al. Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids Journal of Neurotrauma 3/20/2012 [PMID: 21895519]
Gotoh T, Oyadomari S, Mori K, Mori M Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J. Biol. Chem., 2002-01-22;277(14):12343-50. 2002-01-22 [PMID: 11805088] (Western Blot, Human)	Western Blot	Human

Array MAB1800

• HSP60 Antibodies
• HSP60 ELISA Kits
• HSP60 Lysates
• HSP60 Proteins
• HSP60 ELISA