DNAJB6 Antibody (2C11-C1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 9 of 9.

Publications using H00010049-M01	Applications	Species
Folke J, Arkan S, Martinsson I et al. DNAJB6b is Downregulated in Synucleinopathies Journal of Parkinson's Disease 2021-10-12 [PMID: 34334418]
Qian FY, Guo YD, Zu J et al. A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy Acta neuropathologica communications 2021-02-08 [PMID: 33557929] (IF/IHC, Human)	IF/IHC	Human
Palmio J, Jonson PH, Inoue M et al. Mutations in the J domain of DNAJB6 cause dominant distal myopathy Neuromuscul. Disord. 2019-11-19 [PMID: 31955980] (IHC-Fr, Human)	IHC-Fr	Human
Hong YM, Hong Y, Choi YG et al. The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss. Oxid Med Cell Longev 2017-02-09 [PMID: 28280525]
Ding Y, Long PA, Bos JM et al. A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene. JCI Insight 2016-09-08 [PMID: 27642634] (WB)	WB
Bengoechea R, Pittman SK, Tuck EP et al. Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D. Hum. Mol. Genet. 2015-09-11 [PMID: 26362252] (WB, Human)	WB	Human
Stein KC, Bengoechea R, Harms MB et al. Myopathy-Causing Mutations in an Hsp40 Chaperone Disrupt Processing of Specific Client Conformers. J. Biol. Chem. 2014-06-11 [PMID: 24920671] (WB, Human) Details: Used in WB at 1:500 dilution; Figure 6 C - Extracts of HeLa cells transfected with various DNAJB6b constructs or untransfected cells/control processed for WB with TDP-43, DNAJB6b, HSP70 and GAPDH antibodies. Figure 7C - WB of DNAJB6b and GAPDH on fibroblasts from three independent disease control patients (C1, C2, C3) having sporadic amyotrophic lateral sclerosis and three different patients from the same family having the DNAJB6-F93L mutation (P1, P2, P3).	WB	Human
Blandin G, Marchand S, Charton K et al. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Skelet Muscle 2013-02-15 [PMID: 23414517] (WB, Human)	WB	Human
Edo De Bock C, Lin Z, Mekkawy AH et al. Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion. Int J Oncol. 2010-05-01 [PMID: 20372789]

Array H00010049-M01

• DNAJB6 Antibodies
• DNAJB6 Lysates
• DNAJB6 Proteins