Hepcidin Antimicrobial Peptide Antibody (4C5) Summary
Additional Information |
Recombinant monoclonal antibody expressed in HEK293F cells |
Immunogen |
A synthesized peptide derived from Human Hepcidin Antimicrobial Peptide [UniProt P81172] |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Rabbit |
Gene |
HAMP |
Purity |
Affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- ELISA
- Immunohistochemistry 1:50-1:200
- Western Blot 1:500-1:5000
|
Packaging, Storage & Formulations
Storage |
Store at -20 to -70C. Avoid freeze-thaw cycles. |
Buffer |
PBS, pH 7.4, 150mM NaCl and 50% glycerol |
Preservative |
0.02% Sodium Azide |
Purity |
Affinity purified |
Alternate Names for Hepcidin Antimicrobial Peptide Antibody (4C5)
Background
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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