Hepcidin Antimicrobial Peptide Products

Description

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

Bioinformatics

Entrez	57817 Human
Uniprot	AAH20612 Human NM_021175 Human NP_066998.1 Human P81172 Human
Product By Gene ID	57817
Alternate Names	hepcidin antimicrobial peptide HEPCPutative liver tumor regressor HFE2Bhepcidin LEAP-1 LEAP1PLTR Liver-expressed antimicrobial peptide 1