GPR39 Antibody [DyLight 488] Summary
Immunogen |
A synthetic peptide made to an internal region of the human GPR39 protein (within residues 400-500). [Swiss-Prot O43194] |
Localization |
Cell membrane; Multi-pass membrane protein. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
GPR39 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 1:50
- Immunohistochemistry-Paraffin 1:50
|
Application Notes |
Optimal dilution of this antibody should be experimentally determined. |
Reactivity Notes
Mouse reactivity reported in scientific literature (PMID: 25604641)
Packaging, Storage & Formulations
Storage |
Store at 4C in the dark. |
Buffer |
50mM Sodium Borate |
Preservative |
0.05% Sodium Azide |
Purity |
Immunogen affinity purified |
Notes
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Alternate Names for GPR39 Antibody [DyLight 488]
Background
G protein-coupled receptor 39 is an important receptor in the Ghrelin family pathway, and plays an important role in hypertension and adipogenesis. When obestatin binds GPR39, vasodilation occurs in the heart and pancreas, as an effect of pituitary growth hormone effects there. This reaction seems to be protective in these tissues and decreases the effects of diabetes and hypercholesterolemia. However, overexpression of GPR39 is implicated in the formation of squamous cell carcinoma in the esophagus. In this cancer, metastases have inordinately high levels of GPR39.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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