GLUT9 Antibody

GLUT9 (glucose transporter 9; SLC2A9) is a multi-pass membrane transporter protein which primarily transport urate and fructose, and may also implicate in urate reabsorption by proximal tubules as well as the transportation of glucose at low rate. GLUT9 belongs to sugar transporter (TC 2.A.1.1) family and SLC2A9 gene encodes two transcripts: a long isoform (GLUT9L/SLC2A9L) and a short isoform (GLUT9S/SLC2A9S). Placenta is one of the few tissues that express both variants suggesting their role in placental hexose transport, and GLUT9 has been shown to transport both glucose and fructose with about 3-fold higher affinity for glucose. GLUT9 has emerged as a high-capacity urate transporter which influences serum uric acid levels; and GLUT9L and GLUT9S isoforms shows strong expression in the basolateral and apical membranes, respectively, of proximal renal tubular cells. GLUT9 is an important modulator responsible for the reabsorption of urate in the apical membrane of the renal proximal tubules, and loss-of-function mutations in GLUT9 gene results in functional impairment associated with renal hypouricemia type 2 (RHUC2), a disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-06271	Applications	Species
Ota-Kontani A, Hirata H, Ogura M et al. Comprehensive analysis of mechanism underlying hypouricemic effect of glucosyl hesperidin Biochem. Biophys. Res. Commun. 2019-11-08 [PMID: 31711647] (WB, Mouse)	WB	Mouse
Roma A, Ovadje P, Steckle M et al. Selective Induction of Apoptosis by Azadarichta indica Leaf Extract by Targeting Oxidative Vulnerabilities in Human Cancer Cells. J Pharm Pharm Sci. 2015-11-01 [PMID: 26626256] (WB, Human) Details: SOD1/Cu-Zn SOD antibody was used for WB analysis of lysates from Jurkat /E6-1 cells that were treated or not with aqueous or ethanolic Azadarichta indica/neem leaf extracts (Figure 7).	WB	Human

Array NBP1-06271

• GLUT9 Antibodies
• GLUT9 Lysates
• GLUT9 Proteins