GluR7/GRIK3 Antibody (1059901) [Unconjugated] Summary
Immunogen |
Human GluR7/GRIK3 containing peptide. Accession # Q13003 |
Specificity |
Detects human GluR7/GRIK3 in direct ELISA.
|
Source |
N/A |
Isotype |
IgG2b |
Clonality |
Monoclonal |
Host |
Mouse |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 5-25 ug/mL
|
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Reconstitution Instructions |
Reconstitute at 0.5 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for GluR7/GRIK3 Antibody (1059901) [Unconjugated]
Background
GluR7 is a receptor for glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain. This gene can co-assemble with GRIK4 or GRIK5 to form heteromeric receptors. GluR7 is one of the five subtypes of kainate receptors. Kainate receptors are widely expressed in the CNS and are involved in the regulation of transmitter release, synapse formation, and in the pathophysiology of brain diseases. Genetic variants in the GluR7 gene are associated with schizophrenia, major depression, and bipolar disorder.
- Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3.
- Matute C. "Therapeutic Potential of Kainate Receptors". CNS Neuroscience & Therapeutics. 2011 Dec; 17(6):661.
- Begni S, Popoli M, Moraschi S, Bignotti S, Tura G.B, Gennarelli M., "Association Between the Ionotropic Glutamate Receptor Kainate 3 (GRI3) Ser310Ala Polymorphism and Schizophrenia". Mol Psychiatry. 2002; 7(4):416.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for GluR7/GRIK3 Antibody (MAB11328) (0)
Secondary Antibodies
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