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FoxP3 Antibody (3G3) [DyLight 650]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow
Clone
3G3
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-56582AF350
Alexa Fluor 405
NB100-56582AF405
Alexa Fluor 488
NB100-56582AF488
Alexa Fluor 532
NB100-56582AF532
Alexa Fluor 594
NB100-56582AF594
Alexa Fluor 647
NB100-56582AF647
Alexa Fluor 700
NB100-56582AF700
Alexa Fluor 750
NB100-56582AF750
Allophycocyanin
NBP2-26671
Biotin
NB100-56582B
DyLight 350
NB100-56582UV
DyLight 405
NB100-56582V
DyLight 488
NB100-56582G
DyLight 550
NB100-56582R
DyLight 594
NB100-56582DL594
DyLight 680
NB100-56582FR
DyLight 755
NB100-56582IR
FITC
NBP2-26668
Janelia Fluor 549
NB100-56582JF549
Janelia Fluor 646
NB100-56582JF646
PE
NBP2-33297PE
PerCP
NB100-56582PCP
Unconjugated
NB100-56582
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB100-56582
BSA Free
NB100-56582SS
Azide Free
NBP2-33297
BSA Free
NB100-56582
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FoxP3 Antibody (3G3) [DyLight 650] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Full-length His-tagged murine FOXP3 was used as the immunogen. The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein (NP_001107849).
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FOXP3
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for FoxP3 Antibody (3G3) [DyLight 650]

  • AIID
  • AIIDMGC141961
  • DIETER
  • forkhead box P3
  • Forkhead Box Protein P3
  • FoxP3
  • FOXP3delta7
  • immune dysregulation, polyendocrinopathy, enteropathy, X-linked
  • Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked
  • IPEX
  • JM2
  • MGC141961
  • MGC141963
  • PIDX
  • PIDXMGC141963
  • SCURFIN
  • XPID
  • XPIDpolyendocrinopathy, enteropathy, X-linked

Background

Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for FoxP3 Antibody (NB100-56582C). (Showing 1 - 3 of 3 FAQ).

  1. Does FoxP3 antibodies comes in lyophilized form?
    • FoxP3 antibodies, aka JM2 IPEX, and Scurfin antibodies, have the following products in lyophilized form: NBP1-18319, AF3240.
  2. What the theoretical molecular weight for FoxP3 antibodies?
    • The TMW of FoxP3 antibodies is approximately 47 - 52 kDa.
  3. What is the immunogen sequence of this FoxP3 antibody?
    • The full-length His-tagged murine FOXP3 was used as the immunogen.  The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein.

Secondary Antibodies

 

Isotype Controls

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Research Areas for FoxP3 Antibody (NB100-56582C)

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Blogs on FoxP3.

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Meeting Report: 2nd International Antibody Validation Meeting
Bio-Techne brands Novus Biologicals® and R&D Systems® were proud to support the 2nd International Antibody Validation Meeting held at Bath University, on the 15-16 September, 2016. Almost 100 participants from around the world, including funde...  Read full blog post.
FOXP3
Is has been established that the regulatory transcription factor FOXP3 (a member of the forkhead/winged-helix family of transcription factors) is imperative to immune system homeostasis through CD4+CD25+ regulatory T cell function.  Distinctively, ...  Read full blog post.
FOXP3 is a Master Regulator of T Regulatory (Treg) Cells
FOXP3, a member of forkhead/winged-helix family of transcription factors acts as a "master" regulator for the development and suppressive function of regulatory T cells (Tregs). Its constitutive expression is necessary for the suppressive function of ...  Read full blog post.
FOXP3: Master Regulatory Transcriptional Factor
FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-regulatory genes. Treg cells are a population of T lymphocytes that have critical roles in the immune system hom...  Read full blog post.
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Bioinformatics

Gene Symbol FOXP3