FoxJ1/HFH4 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

FoxJ1 (Forkhead box protein J1; also HFH4) is a 55-65 kDa, class 1 member of the HNF-3/forkhead gene family of transcription factors. Its observed MW is higher than its predicted MW (45 kDa), suggesting anomalous migration on SDS-PAGE. FoxJ1 promotes the expression of cilia in respiratory, oviduct and choroid plexus epithelium, and maintains T cell tolerance to self-antigens. Human FoxJ1 is 421 amino acids (aa) in length, and contains one forkhead DNA binding domain (aa's 120‑210). The presence of basic residues in the forkhead domain makes FoxJ1 a class 1 Fox protein. There is potential splice variant that contains a 25 aa substation for aa 262-287. Over aa 306-421, human FoxJ1 shares 88% aa with mouse FoxJ1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 3 applications: ICC, IHC, IHC-P.

Showing Publications 1 - 10 of 10.

Publications using AF3619	Applications	Species
Wei, H;Wu, X;Withrow, J;Cuevas-Diaz Duran, R;Singh, S;Chaboub, LS;Rakshit, J;Mejia, J;Rolfe, A;Herrera, JJ;Horner, PJ;Wu, JQ; Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury Cell reports 2023-05-06 [PMID: 37149868] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo et al. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response Nature Aging 2022-01-25 [PMID: 37117754]
Chen M, Pekosz A, Villano JS et al. Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants bioRxiv : the preprint server for biology 4/12/2022 [PMID: 35441175]
IT Stancil, JE Michalski, D Davis-Hall, HW Chu, JA Park, CM Magin, IV Yang, BJ Smith, E Dobrinskik, DA Schwartz Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional Nature Communications, 2021-07-27;12(1):4566. 2021-07-27 [PMID: 34315881] (IHC, Human)	IHC	Human
R Robinot, M Hubert, GD de Melo, F Lazarini, T Bruel, N Smith, S Levallois, F Larrous, J Fernandes, S Gellenonco, S Rigaud, O Gorgette, C Thouvenot, C Trébeau, A Mallet, G Duménil, S Gobaa, R Etournay, PM Lledo, M Lecuit, H Bourhy, D Duffy, V Michel, O Schwartz, LA Chakrabart SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance Nature Communications, 2021-07-16;12(1):4354. 2021-07-16 [PMID: 34272374] (ICC, Human)	ICC	Human
LN Manganas, I Durá, S Osenberg, F Semerci, M Tosun, R Mishra, L Parkitny, JM Encinas, M Maletic-Sa BASP1 labels neural stem cells in the neurogenic niches of mammalian brain Scientific Reports, 2021-03-10;11(1):5546. 2021-03-10 [PMID: 33692421] (IHC, Mouse)	IHC	Mouse
MN Ali, M Mori, TCJ Mertens, P Siddhuraj, JS Erjefält, P Önnerfjord, PS Hiemstra, A Egesten Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells Sci Rep, 2019-10-29;9(1):15566. 2019-10-29 [PMID: 31664154] (IHC, Human)	IHC	Human
Gefitinib, an EGFR Tyrosine Kinase inhibitor, Prevents Smoke-Mediated Ciliated Airway Epithelial Cell Loss and Promotes Their Recovery PLoS ONE, 2016-08-17;11(8):e0160216. 2016-08-17 [PMID: 27532261] (IHC-P, Human)	IHC-P	Human
Gerovac BJ, Valencia M, Baumlin N et al. Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch Dependent Manner.. Am. J. Respir. Cell Mol. Biol. [PMID: 24754775]
Casalino-Matsuda SM, Monzon ME, Day AJ, Forteza RM Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium. Am. J. Respir. Cell Mol. Biol., 2008-08-28;40(3):277-85. 2008-08-28 [PMID: 18757307] (IHC-P, Human)	IHC-P	Human

Array AF3619

• FoxJ1/HFH4 Antibodies
• FoxJ1/HFH4 Proteins