PITX2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PITX2 (PITuitary homeoboX 2; also ARP1 and RIEG) is a 33-36 kDa nuclear member of the bicoid subfamily, paired homeobox family of transcription factors. It is widely expressed in the embryo, and serves as the earliest known marker for pituitary gland development. A long isoform commonly called PITX2C also plays a very key role in the establishment of left-right organ asymmetry. PITX2 appears in multiple germ layer derivatives, and it appears that one of its important functions is to integrating retinoic acid and Wnt/ beta -catenin signaling. The N- and C-terminal regions of PITX2 normally interact noncovalently, rendering PITX2 inactive.  Over aa 149‑317, human and mouse PITX2 are identical in aa sequence.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Gecko.

We have publications tested in 2 applications: ICC, IHC.

Showing Publications 1 - 8 of 8.

Publications using AF7388	Applications	Species
Su, D;Eliason, S;Sun, Z;Shao, F;Amendt, BA; Wolf-Hirschhorn Syndrome Candidate 1 (Whsc1) Methyltransferase Signals Via a Pitx2-miR-23/24 Axis to Effect Tooth Development The Journal of biological chemistry 2023-10-06 [PMID: 37806494] (IHC, Mouse)	IHC	Mouse
KS Brink, JI Henríquez, TM Grieco, JR Martin Del, K Fu, JM Richman Tooth Removal in the Leopard Gecko and the de novo Formation of Replacement Teeth Frontiers in Physiology, 2021-05-04;12(0):576816. 2021-05-04 [PMID: 34012403] (IHC, Gecko)	IHC	Gecko
YH Zhang, M Xu, X Shi, XL Sun, W Mu, H Wu, J Wang, S Li, P Su, L Gong, M He, M Yao, QF Wu Cascade diversification directs generation of neuronal diversity in the hypothalamus Cell Stem Cell, 2021-04-21;0(0):. 2021-04-21 [PMID: 33887179] (IHC, Mouse)	IHC	Mouse
Mason Sweat, Yan Sweat, Wenjie Yu, Dan Su, Riley J. Leonard, Steven L. Eliason et al. The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche Stem Cells 2021-06-01 [PMID: 33529466]
Gantner C, Cota-Coronado A, Thompson L, Parish C An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions STAR Protoc 10/28/2020 [PMID: 33111103]
Wenjie Yu, Zhao Sun, Yan Sweat, Mason Sweat, Shankar Rengasamy Venugopalan, Steven Eliason et al. Pitx2-Sox2-Lef-1 interactions specify progenitor oral/dental epithelial cell signaling centers Development 2020-01-01 [PMID: 32439755]
CW Gantner, IR de Luzy, JA Kauhausen, N Moriarty, JC Niclis, CR Bye, V Penna, CPJ Hunt, CM Ermine, CW Pouton, D Kirik, LH Thompson, CL Parish Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease Cell Stem Cell, 2020-02-13;0(0):. 2020-02-13 [PMID: 32059808] (ICC, Mouse, Rat)	ICC	Mouse, Rat
IR de Luzy, JC Niclis, CW Gantner, JA Kauhausen, CPJ Hunt, C Ermine, CW Pouton, LH Thompson, CL Parish Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian Disease J. Neurosci., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641054] (ICC, Human)	ICC	Human

Array AF7388

• PITX2 Antibodies
• PITX2 Lysates
• PITX2 Proteins