SERCA2 ATPase Antibody (2A7-A1)

ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are comprised of a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Porcine.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using NB300-581	Applications	Species
Tanton H, Sewastianik T, Seo HS et al. A novel beta-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer Science advances 2022-04-29 [PMID: 35486727] (ICC/IF)	ICC/IF
Hammad AS, Yu F, Botheju WS Et al. Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis Cell calcium 2021-10-23 [PMID: 34715400] (ICC/IF, Mouse)	ICC/IF	Mouse
Uchida Y, Yamamoto Y, Sakisaka T Trans-2-enoyl-CoA reductase limits Ca2+ accumulation in the endoplasmic reticulum by inhibiting the Ca2+ pump SERCA2b The Journal of biological chemistry 2021-01-19 [PMID: 33482198]
Xie D, Geng L, Xiong K et al. Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase Circ. Res. 2020-03-26 [PMID: 32212953] (WB)	WB
Chung YJ, Luo A, Park KC et al. Iron deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity JCI Insight 2019-02-19 [PMID: 30779710] (WB, Mouse)	WB	Mouse
Schroeder MA, Ali MA, Hulikova A et al. Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics. Proc Natl Acad Sci U S A 2013-03-05 [PMID: 23431149] (WB, Rat)	WB	Rat
Klug D, Boule S, Wissocque L et al. Right Ventricular Pacing With Mechanical Dyssynchrony Causes Apoptosis Interruptus and Calcium Mishandling Can J Cardiol 2012-10-10 [PMID: 23062666] (WB, Porcine)	WB	Porcine
Garcia-Perez C et al. Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle. J Biol Chem;283(47):32771-80. 2008-11-21 [PMID: 18790739] (IF/IHC)	IF/IHC
Anyatonwu GI et al. Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A;104(15):6454-9. 2007-04-10 [PMID: 17404231] (IP)	IP
Prasad AM et al. Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca2+ signaling in neonatal rat cardiac myocytes. Am J Physiol Cell Physiol;292(6):C2269-75. 2007-06-01 [PMID: 17287366] (ICC/IF)	ICC/IF
Khan SA et al. Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A;101(45):15944-8. 2004-11-09 [PMID: 15486091] (IP)	IP
Krizaj D, Liu X, Copenhagen DR et al. Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum). J Comp Neurol. 2004-08-01 [PMID: 15236230] (IF/IHC)	IF/IHC
Spragg DD et al. Regional alterations in protein expression in the dyssynchronous failing heart. Circulation;108(8):929-32. 2003-08-26 [PMID: 12925451] (WB)	WB
Tupling AR et al. Sarcolipin overexpression in rat slow twitch muscle inhibits sarcoplasmic reticulum Ca2+ uptake and impairs contractile function. J Biol Chem;277(47):44740-6. 2002-11-22 [PMID: 12237298] (ICC/IF)	ICC/IF
Asahi M et al. Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs). J Biol Chem;277(30):26725-8. 2002-07-26 [PMID: 12032137] (IP)	IP
Movsesian MA et al. Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium. Circulation;90(2):653-7. 1994-08-01 [PMID: 8044934] (WB)	WB
Show All 16 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	1 reviewed by: Verified Customer	IHC-P	Rat	12/16/2020	View Summary Application Immunohistochemistry-Paraffin Sample Tested cardiac tissue Species Rat Lot UC276383 Comments Comments 1:900 dilution Nuclear counterstain
Enlarge	5 reviewed by: Verified Customer	ICC	Human	08/01/2018	View Summary Application Immunocytochemistry Sample Tested hela cell Species Human Lot SE 248905

Array NB300-581

• SERCA2 ATPase Antibodies
• SERCA2 ATPase ELISA Kits
• SERCA2 ATPase Proteins