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Filamin A Antibody (4E10-1B2)

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Western Blot: Filamin A Antibody (4E10-1B2) [H00002316-M01] - FLNA monoclonal antibody (M01), clone 4E10-1B2 Analysis of FLNA expression in HL-60.
Western Blot: Filamin A Antibody (4E10-1B2) [H00002316-M01] - FLNA monoclonal antibody (M01), clone 4E10-1B2 Analysis of FLNA expression in HL-60.
Immunohistochemistry-Paraffin: Filamin A Antibody (4E10-1B2) [H00002316-M01] - Analysis of monoclonal antibody to FLNA on formalin-fixed paraffin-embedded human lymphoma tissue. Antibody concentration 1.5 ug/ml.
Proximity Ligation Assay: Filamin A Antibody (4E10-1B2) [H00002316-M01] - Analysis of protein-protein interactions between GP1BA and FLNA. HeLa cells were stained with anti-GP1BA rabbit purified polyclonal 1:1200 and ...read more
ELISA: Filamin A Antibody (4E10-1B2) [H00002316-M01] - Filamin A Antibody (4E10-1B2) [H00002316-M01] - Detection limit for recombinant GST tagged FLNA is approximately 0.03ng/ml as a capture antibody.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, Func, ICC/IF, IHC
Clone
4E10-1B2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Filamin A Antibody (4E10-1B2) Summary

Description
Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen
FLNA (AAH14654, 1 a.a. ~ 838 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP
Specificity
FLNA - filamin A, alpha (actin binding protein 280)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FLNA
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Proximity Ligation Assay
  • Western Blot 1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.
Publications
Read Publications using H00002316-M01.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Filamin A Antibody (4E10-1B2)

  • ABP-280
  • ABP-280DKFZp434P031
  • ABPX
  • actin binding protein 280
  • Actin-binding protein 280
  • Alpha-filamin
  • CVD1
  • EC 2.1.1.43
  • EC 6.3.4.4
  • Endothelial actin-binding protein
  • Filamin A
  • filamin A, alpha (actin binding protein 280)
  • filamin A, alpha
  • Filamin-1
  • filamin-A
  • FLN
  • FLN1
  • FLN1OPD
  • FLNA
  • FLN-A
  • FMD
  • MNS
  • NHBP
  • Non-muscle filamin
  • OPD1
  • OPD2
  • XLVD
  • XMVD

Background

Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Filamin A Antibody (H00002316-M01)(14)


Showing Publications 1 - 10 of 14. Show All 14 Publications.
Publications using H00002316-M01 Applications Species
Marie-Lise J, Sana S, Zsombor K et al. Filamin A organizes ?-aminobutyric acid type B receptors at the plasma membrane. Nat Commun. 2023-01-03 [PMID: 36596803]
Donatella T, Genesio M, Federica M et al. Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells. Mol Cell Endocrinol. 2021-01-08 [PMID: 33428965]
R C, E G, D T et al. The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells. Cancer Lett. 2020-10-16 [PMID: 33075426]
Peverelli E, Giardino E, Treppiedi D et al. A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment. Int J Cancer 2017-12-11 [PMID: 29226331]
Mingione A, Verdelli C, Ferrero S et al. Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors. J Mol Endocrinol 2016-11-21 [PMID: 27872158]
Gay O, Gilquin B, Assard N et al. Refilins are short-lived Actin-bundling proteins that regulate lamellipodium protrusion dynamics. Biol Open 2016-10-15 [PMID: 27744291]
Vitali E, Cambiaghi V, Zerbi A et al. Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours. Endocr Relat Cancer 2016-03-01 [PMID: 26733502]
Bezie S, Picarda E, Tesson L et al. Fibrinogen-Like Protein 2/Fibroleukin Induces Long-Term Allograft Survival in a Rat Model through Regulatory B Cells. PLoS One. 2015-03-12 [PMID: 25763980]
Parrini E, Mei D, Pisanti MA et al. Familial periventricular nodular heterotopia, epilepsy and Melnick-Needles Syndrome caused by a single FLNA mutation with combined gain-of-function and loss-of-function effects. J Med Genet. 2015-03-19 [PMID: 25755106]
Peverelli E, Giardino E, Treppiedi D et al. Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells. Endocrinology. 2014-05-14 [PMID: 24828612]
Show All 14 Publications.

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Bioinformatics

Gene Symbol FLNA
Entrez
OMIM
Uniprot