Ryanodine Receptor Antibody (34C) - BSA Free

The Ryanodine Receptor (RyR) is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum (SR) and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule and the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle and areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain; and RyR-3 is found in smooth muscle and the brain (striatum, thalamus and hippocampus). In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta and cardiac which correlate loosely to the mammalian RyR-1, RyR-3 and RyR-2 isoforms respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 applications: B/N, ICC/IF.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB300-543	Applications	Species
Jordan T et al. Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition. J Cell Sci; 117(Pt 25):6175-83. 2004-12-01 [PMID: 15564379] (ICC/IF)	ICC/IF
Liu Z et al. Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor localization of its amino terminus. Proc Natl Acad Sci U S A 98:6104-9. 2001-01-01 [PMID: 11353864]
Yamada KA et al. Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum. J Cardiovasc Pharmacol 36:14-21. 2000-01-01 [PMID: 10892655]
Chan SL et al. Presenilin-1 mutations increase levels of ryanodine receptors calcium release in PC12 cells cortical neurons. J Biol Chem 275:18195-200. 2000-01-01 [PMID: 10764737]
Moore RA et al. A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein function. J Cell Biol 140:843-51. 1998-01-01 [PMID: 9472036]
Protasi F et al. Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J Cell Biol 140:831-42. 1998-01-01 [PMID: 9472035]
Chen SR et al. Positioning of major tryptic fragments in the Ca2+ release channel (ryanodine receptor) resulting from partial digestion of rabbit skeletal muscle sarcoplasmic reticulum. J Biol Chem 268:22642-9. 1993-01-01 [PMID: 8226772]
Liu G et al. Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls. J Biol Chem 269 (52):33028-34. 1994-12-30 [PMID: 7806531] (B/N)	B/N
Naukkarinen A. Myotonic dystrophy type 2 (DM2): Diagnostic methods and molecular pathology . 2011; University of Helsinki, Finland.
Airey JA et al. Three ryanodine receptor isoforms exist in avian striated muscles. Biochemistry 32:5739-45. 1993-01-01 [PMID: 7684927]
Airey JA et al. Identification localization of two triad junctional foot protein isoforms in mature avian fast twitch skeletal muscle. J Biol Chem 265:14187-94. 1990-01-01 [PMID: 2387846]
Walton PD et al. Ryanodine inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons. J Cell Biol 113:1145-57. 1991-01-01 [PMID: 1645737]
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Array NB300-543

• Ryanodine Receptor Antibodies