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DRP1 Antibody (4E11B11)

Images

 
Western Blot: DRP1 Antibody (4E11B11) [NBP2-23489] - Analysis using DRP1 mouse mAb in (1) A549 and (2) Jurkat cell lysates.
Immunohistochemistry: DRP1 Antibody (4E11B11) [NBP2-23489] - Analysis of paraffin-embedded human cerebellum tissues using DRP1 mouse mAb with DAB staining.
Western Blot: DRP1 Antibody (4E11B11) [NBP2-23489] - Analysis using DRP1 mAb in human DRP1 recombinant protein. (Expected MW is 41.8 kDa)
Western Blot: DRP1 Antibody (4E11B11) [NBP2-23489] - Analysis using DRP1 mAb in (1) HEK293 and (2) DRP1 hIgGFc transfected HEK293 cell lysate.
Immunohistochemistry: DRP1 Antibody (4E11B11) [NBP2-23489] - Analysis of paraffin-embedded human ovarian cancer tissues using DRP1 mouse mAb with DAB staining.

Product Details

Summary
Reactivity Hu, Rt, Mu, Bv, ChHaSpecies Glossary
Applications WB, ELISA, IHC
Clone
4E11B11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

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DRP1 Antibody (4E11B11) Summary

Immunogen
Partial recombinant human DRP1 (between residues 100-250) expressed in E. coli. [Uniprot: O00429]
Predicted Species
Mouse (94%), Bovine (90%), Chinese Hamster (97%). Backed by our 100% Guarantee.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
DNM1L
Purity
Ammonium sulfate precipitation
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:10000
  • Immunohistochemistry 1:200 - 1:1000
  • Immunohistochemistry-Paraffin 1:200 - 1:1000
  • Western Blot 1:500 - 1:2000
Control
Jurkat Whole Cell Lysate
Publications
Read Publications using
NBP2-23489 in the following applications:

Reactivity Notes

Use in Rat reported in scientific literature (PMID:32693013).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 0.5% protein stabilizer
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Ammonium sulfate precipitation

Alternate Names for DRP1 Antibody (4E11B11)

  • DLP1
  • DNM1L
  • DRP1
  • DRP1Dnm1p/Vps1p-like protein
  • DVLP
  • DVLPEC 3.6.5.5
  • Dymple
  • DYMPLEDYNIV-11
  • dynamin 1-like
  • Dynamin family member proline-rich carboxyl-terminal domain less
  • dynamin-1-like protein
  • Dynamin-like protein 4
  • Dynamin-like protein IV
  • Dynamin-like protein
  • Dynamin-related protein 1
  • FLJ41912
  • HdynIV
  • VPS1

Background

A human dynamin-related protein, DRP1 contributes to mitochondrial division in mammalian cells. It plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for DRP1 Antibody (NBP2-23489)(2)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 3 applications: FLOW, ICC/IF, WB.


Filter By Application
FLOW
(1)
ICC/IF
(1)
WB
(1)
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Rat
(1)
All Species

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for DRP1 Antibody (NBP2-23489) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional DRP1 Products

Research Areas for DRP1 Antibody (NBP2-23489)

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Blogs on DRP1.

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress
By Jamshed Arslan, Pharm. D., PhD. December 1 is the World AIDS Day. Despite the combination antiretroviral therapy, 10-25% of Human Immunodeficiency Virus (HIV)-positive individuals report neurocognitive impairm...  Read full blog post.

Understanding Mitophagy Mechanisms: Canonical PINK1/Parkin, LC3-Dependent Piecemeal, and LC3-Independent Mitochondrial Derived Vesicles
By Christina Towers, PhD What is Mitophagy?The selective degradation of mitochondria via double membrane autophagosome vesicles is called mitophagy. Damaged mitochondria can generate harmful amounts of reactive ox...  Read full blog post.

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease
 By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...  Read full blog post.

Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis.
Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mech...  Read full blog post.

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Bioinformatics

Gene Symbol DNM1L
Entrez
Uniprot