BAK Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BAK (Bcl-2 homologous antagonist/killer; also BAK1) is a 25‑30 kDa member of the BCL-2 family of proteins. It is widely expressed, and participates in the apoptotic cycle. BAK is an outer mitochondrial membrane protein that is inactive as a Zn-dependent homodimer. Upon activation by p53 or tBID, BAK oligomerizes, creating a pore in the mitochondrial membrane and allowing for cytochrome C release. Human BAK is 211 amino acids (aa) in length and contains three BCL-2 homology domains (aa 74‑88, 117‑136 and 169‑184), a Zn-binding region (aa 160‑166) and a C-terminal transmembrane segment (aa 188‑205). Amino acids 67‑94 mediate oligomerization of BAK. There are two potential isoform variants; one shows an alternate start site at Met96, while a second shows a deletion of aa 46‑66. Over amino acids 53-72, human BAK shares 55% aa identity with mouse BAK.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 5 of 5.

Publications using AF816	Applications	Species
K Ibraheem, AMA Yhmed, MM Nasef, NT Georgopoul TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40 Cells, 2022-10-18;11(20):. 2022-10-18 [PMID: 36291141] (Western Blot, Human)	Western Blot	Human
Khalidah Ibraheem, Albashir M. A. Yhmed, Tahir Qayyum, Nicolas P. Bryan, Nikolaos T. Georgopoulos CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis Cell Death Discovery 2019-12-04 [PMID: 31815003]
A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis Oncogene, 2016-11-21;0(0):. 2016-11-21 [PMID: 27869172] (Western Blot, Human)	Western Blot	Human
Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut, 2006-07-13;56(2):243-52. 2006-07-13 [PMID: 16840505] (Western Blot, Human)	Western Blot	Human
Li CQ, Robles AI, Hanigan CL, Hofseth LJ, Trudel LJ, Harris CC, Wogan GN Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res., 2004-05-01;64(9):3022-9. 2004-05-01 [PMID: 15126337] (Western Blot, Human)	Western Blot	Human

Array AF816

• BAK Antibodies
• BAK ELISA Kits
• BAK Lysate
• BAK Protein
• BAK Proteins and Enzymes