Desmocollin-1 Antibody

The protein encoded by the Desmosomal Protein gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. (provided by RefSeq)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Block/Neutralize, IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-88099	Applications	Species
Verkerk AJMH, Andrei D, Vermeer MCSC et al. Disruption of TUFT1, a Desmosome-Associated Protein, Causes Skin Fragility, Woolly Hair, and Palmoplantar Keratoderma The Journal of investigative dermatology 2023-09-15 [PMID: 37716648] (IHC-Fr, Human)	IHC-Fr	Human
Choi HY, Ruel I, Genest J. Identification of Docetaxel as a Potential Drug to Promote HDL Biogenesis Frontiers in Pharmacology 2021-05-21 [PMID: 34093205] (Block/Neutralize)	Block/Neutralize
Miyazaki H, Tsunoi Y, Akagi T et al. EMSY expression affects multiple components of skin barrier with relevance to atopic dermatitis Journal of Allergy and Clinical Immunology 2019-05-01 [PMID: 31158401] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Min D, Lee W, Bae IH et al. Bioprinting of Biomimetic Skin containing Melanocytes. Exp. Dermatol. 2017-04-28 [PMID: 28453913] (Human)		Human
Paavilainen L, Edvinsson A, Asplund A et al. The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells. J Histochem Cytochem 2010-03-01 [PMID: 19901271]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Mickaël Pinto	IHC-P	Canine	11/07/2019	View Summary Application Immunohistochemistry-Paraffin Sample Tested Paraffin sections of canine folicular skin (dogs with pemphigus foliaceus) Species Canine Lot C113886 Comments Comments ABSTRACT Background Pemphigus foliaceus is the most common autoimmune disease in dogs. It is characterized histologically by subcorneal pustules and acantholysis. Desmocollin-1 is the major target antigen of autoantibodies in dogs. Previous immunostaining studies have shown possible pathogenic similarities between canine and human pemphigus. Objetives To investigate the pathogenesis of acantholysis in canine Pemphigus Foliaceus, we decided to review the main histopathological findings and observe the variations of the labeling of desmocollin-1 by immunohistochemistry in skin biopsies from sick dogs. Material and methods Five cases of dogs with Pemphigus Foliaceus were selected and histopathological findings were reviewed by hematoxylin-eosin staining. Then the samples were stained following an immunohistochemical protocol, with an anti-desmocolin-1 antibody. Results The 5 cases presented typical histological characteristics of PFc: pustules in the superficial layers of the epidermis, acantholytic keratinocytes and neutrophilic exocytosis. We have validated the use of the anti-dsc-1 antibody in dogs, for immunhistochemistry in skin biopsies preserved in paraffin. We have observed that, in dogs with PF, the immunohistochemical pattern of desmocollin-1 was altered. Conclusions Staining of desmocollin-1 is altered in dogs with PF. We were able to corroborate the pathogenic mechanisms already demonstrated by immunohistochemistry. Thus, immunohistochemical staining for this protein may be useful in diagnosis. Its use, to study precise mechanisms, is limited and more biotechnologic tools are needed to complement the knowledge on this disease.

Array NBP1-88099

• Desmocollin-1 Antibodies
• Desmocollin-1 ELISA Kits
• Desmocollin-1 Lysate
• Desmocollin-1 Proteins
• Desmocollin-1 Proteins and Enzyme