Kallikrein 7 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human tissue Kallikrein 7 (hK7), also known as stratum corneum chymotryptic enzyme (SCCE), is a member of the human tissue kallikrein family. Full-length hK7 consists of 253 amino acids, with a signal peptide (residues 1-22), short pro peptide (residues 23-29) and mature chain (residues 30-252) (1). Predominantly expressed in the skin, a major physiological function of hK7 is to regulate the desquamation process through proteolysis of the intercellular adhesive structures between corneocytes (2). Thus, it is related to some inflammatory skin diseases, such as psoriasis and chronic itchy dermatitis (3, 4). Studies have shown that one potential physiological activator for hK7 is hK5, another member of the human tissue Kallikrein family. Along with hK14, these three kallikreins form a proteolytic cascade in the stratum corneum (5). The purified, secreted rhK7 corresponds to the pro form. When activated by thermolysin, it displays enzymatic activity towards a fluorogenic synthetic peptide described in the Activity Assay Protocol. This activity can be inhibited by rhSerpin A1, A3, A4, and A5 (R&D Systems, Catalog # 1268‑PI, 1295-PI, 1669-PI, and 1266-PI).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: IHC, IHC-Fr, IHC-P, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 10.

Publications using AF2624	Applications	Species
Ford, NC;Benedeck, RE;Mattoon, MT;Peterson, JK;Mesler, AL;Veniaminova, NA;Gardon, DJ;Tsai, SY;Uchida, Y;Wong, SY; Hair follicles modulate skin barrier function bioRxiv : the preprint server for biology 2024-04-27 [PMID: 38712094] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Khalid Muhammad, Delicia Xavier, Stefan Klein-Hessling, Muhammad Azeem, Tabea Rauschenberger, Krisna Murti et al. NFAT5 Controls the Integrity of Epidermis Frontiers in Immunology 12/9/2021 [PMID: 34956208]
H Ma, A Hockla, C Mehner, M Coban, N Papo, DC Radisky, ES Radisky PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma Sci Rep, 2019-02-12;9(1):1844. 2019-02-12 [PMID: 30755669] (Western Blot, Human)	Western Blot	Human
K Kidana, T Tatebe, K Ito, N Hara, A Kakita, T Saito, S Takatori, Y Ouchi, T Ikeuchi, M Makino, TC Saido, M Akishita, T Iwatsubo, Y Hori, T Tomita Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice EMBO Mol Med, 2018-03-01;0(0):. 2018-03-01 [PMID: 29311134] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Martina S. Elias, Heather A. Long, Carla F. Newman, Paul A. Wilson, Andrew West, Paul J. McGill et al. Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema Journal of Allergy and Clinical Immunology 11/1/2017 [PMID: 28479159]
Frank K.J. Leusink, P.J. van Diest, M.H. Frank, R. Broekhuizen, W. Braunius, S.R. van Hooff et al. The Co-Expression of Kallikrein 5 and Kallikrein 7 Associates with Poor Survival in Non-HPV Oral Squamous-Cell Carcinoma Pathobiology 2/23/2015 [PMID: 26022646]
Dorn , Julia, Gkazepis , Apostolo, Kotzsch , Matthias, Kremer , Marcus, Propping , Corinna, Mayer , Katharin, Mengele , Karin, Diamandis , Elefther, Kiechle , Marion, Magdolen , Viktor, Schmitt , Manfred Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer. Biol Chem, 2014-01-01;395(1):95-107. 2014-01-01 [PMID: 23999494] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Munoz-Repeto I, Garcia M, Kamieniak M, Ramon Y Cajal T, Domingo S, Cazorla A, Garcia Donas J, Hernando Polo S, Garcia Sagredo J, Hernandez E, Lacambra C, Saez R, Robles L, Borrego S, Prat J, Palacios J, Benitez J Phenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray study. Histol Histopathol, 2013-01-01;28(1):133-44. 2013-01-01 [PMID: 23233066] (IHC-P, Human)	IHC-P	Human
Ramani VC, Haun RS The extracellular matrix protein fibronectin is a substrate for kallikrein 7. Biochem. Biophys. Res. Commun., 2008-03-14;369(4):1169-73. 2008-03-14 [PMID: 18343220] (Western Blot, Human)	Western Blot	Human
Chee J, Singh J, Naran A, Misso NL, Thompson PJ, Bhoola KD Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma. Biol. Chem., 2007-11-01;388(11):1235-42. 2007-11-01 [PMID: 17976017] (IHC-P, Human)	IHC-P	Human

Array AF2624

• Kallikrein 7 Antibodies
• Kallikrein 7 ELISA Kits
• Kallikrein 7 Lysate
• Kallikrein 7 Proteins
• Kallikrein 7 Proteins and Enzymes
• Kallikrein 7 ELISA