Desmoglein-3 Antibody (5H10)

Desmoglein 3 (Dsg3) is a member of sub-family the desmoglein (DSGs) and it mainly serves as adhesion component of intercellular desmosome junctions. DSGs serve essential part of the core complex of desmosomes, and together with desmocollin (DSCs), they represents transmembrane proteins which mediate adhesion by transinteracting with cadherins of the opposing cell. Homophilic (e.g., DSG3-DSG3) as well as heterophilic (e.g., DSC3-DSG1) transinteraction have been reported for these proteins and within the desmosome, DSGs/DSCs are anchored to the intracellular plaque proteins plakoglobin, plakophilins, and desmoplakin, the latter of which mediates connection to the intermediate filament cytoskeleton. Desmoglein 3 is predominately expressed in stratified squamous epithelia including epidermis, tongue, tonsil, esophagus and carcinomas. Desmoglein 3 has been characterized as an auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease, wherein the binding of anti-desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Cytometric Bead Assay Standard, ICC/IF, IP, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP1-78984	Applications	Species
Assaf S, Vodo D, Malovitski K et al. Up-regulation of ST18 in pemphigus vulgaris drives a self-amplifying p53-dependent pathomechanism resulting in decreased desmoglein 3 expression Scientific reports 2022-04-08 [PMID: 35396567]
Walter E, Vielmuth F, Rotkopf L et al. Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus. Sci Rep. 2017-06-15 [PMID: 28620161] (WB, Human)	WB	Human
Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H. Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PLoS One. 5(12):e14211. 2010-12-03 [PMID: 21151980] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK 3rd. Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. Exp Dermatol. 15(2):101-9. 2006-02-01 [PMID: 16433681] (IP, WB, Human)	IP, WB	Human
Lucchese A, Mittelman A, Lin MS, Kanduc D, Sinha AA. Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10. J Transl Med. 2(1):43. 2004-12-11 [PMID: 15588331] (Cytometric Bead Assay Standard, Human)	Cytometric Bead Assay Standard	Human
Wahl JK 3rd. Generation of monoclonal antibodies specific for desmoglein family members. Hybrid Hybridomics. 21(1):37-44. 2002-02-01 [PMID: 11991815] (WB, ICC/IF, IP)	WB, ICC/IF, IP
Weiske J, Schoneberg T, Schroder W, Hatzfeld M, Tauber R, Huber O. The fate of desmosomal proteins in apoptotic cells. J Biol Chem. 276(44):41175-81. 2001-11-02 [PMID: 11500511] (ICC/IF, IP, WB, Human)	ICC/IF, IP, WB	Human
Proby CM, Ota T, Suzuki H, Koyasu S, Gamou S, Shimizu N, Wahl JK, Wheelock MJ, Nishikawa T, Amagai M. Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris. Br J Dermatol. 142(2):321-30. 2000-02-01 [PMID: 10730768] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Qi Miao	ICC	Mouse	06/22/2017	View Summary Application Immunocytochemistry Sample Tested Primary skin keratinocytes Species Mouse

Array NBP1-78984

• Desmoglein-3 Antibodies
• Desmoglein-3 ELISA Kits
• Desmoglein-3 Proteins
• Desmoglein-3 Proteins and Enzymes