DDX3 Antibody

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing of this gene generates 2 transcript variants, which are divergent in the 3' UTR.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 4 of 4.

Publications using NB200-194	Applications	Species
Choi Y-J, Lee S-G. The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export. Journal of Cellular Biochemistry. 2011-10-27 [PMID: 22034099]
DeFilippis VR, Alvarado D, Sali T et al. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. J Virol 2010-01-01 [PMID: 19846511]
Schroder M, Baran M, Bowie AG et al. Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. EMBO J 2008-08-01 [PMID: 18636090]
Kang BY, Tsoi S, Zhu S et al. Differential gene expression profiling in HELLP syndrome placentas. Reprod Sci 2008-04-01 [PMID: 18421023]

Array NB200-194

• DDX3 Antibodies