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CXCR4 Antibody [mFluor Violet 500 SE]

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CXCR4 Antibody [mFluor Violet 500 SE] - Vial of mFluor Violet 500 conjugated antibody. mFluor Violet 500 is optimally excited at 410 nm by the Violet laser (405 nm) and has an emission maximum of 501 nm.
CXCR4 Antibody [mFluor Violet 500 SE] - Vial of mFluor Violet 500 conjugated antibody. mFluor Violet 500 is optimally excited at 410 nm by the Violet laser (405 nm) and has an emission maximum of 501 nm.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC, KD, KO
Clonality
Polyclonal
Host
Rabbit
Conjugate
mFluor Violet 500 SE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77067AF350
Alexa Fluor 405
NBP1-77067AF405
Alexa Fluor 488
NBP1-77067AF488
Alexa Fluor 532
NBP1-77067AF532
Alexa Fluor 594
NBP1-77067AF594
Alexa Fluor 647
NBP1-77067AF647
Alexa Fluor 700
NBP1-77067AF700
Alexa Fluor 750
NBP1-77067AF750
Allophycocyanin
NBP1-77067APC
Biotin
NBP1-77067B
CoraFluor 1
NBP1-77067CL1
DyLight 350
NBP1-77067UV
DyLight 405
NBP1-77067V
DyLight 488
NBP1-77067G
DyLight 550
NBP1-77067R
DyLight 594
NBP1-77067DL594
DyLight 650
NBP1-77067C
DyLight 680
NBP1-77067FR
DyLight 755
NBP1-77067IR
FITC
NBP1-77067F
HRP
NBP1-77067H
Janelia Fluor 525
NBP1-77067JF525
Janelia Fluor 549
NBP1-77067JF549
Janelia Fluor 585
NBP1-77067JF585
Janelia Fluor 635
NBP1-77067JF635
Janelia Fluor 646
NBP1-77067JF646
Janelia Fluor 669
NBP1-77067JF669
PE
NBP1-77067PE
PerCP
NBP1-77067PCP
Unconjugated
NBP1-77067
mFluor Violet 450 SE
NBP1-77067MFV450
mFluor Violet 610 SE
NBP1-77067MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-77067
BSA Free
NBP1-77067
BSA Free
NBP1-77067SS
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CXCR4 Antibody [mFluor Violet 500 SE] Summary

Immunogen
Antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human CXCR4 isoform b. The immunogen is located within the first 50 amino acids of CXCR4. Amino Acid Squence: MEGISIYTSDNYTE
Specificity
Human CXCR4 has four isoforms, including isoform a (356aa, 40.2kD), isoform b (352aa, 39.7kD), isoform c (423aa, 47.6kD), and isoform d (385aa, 43.4kD). This antibody detects human isoform b only, but not other human isoforms. Mouse CXCR4 has two isoforms, including isoform 1 (359aa, 40.4kD) and isoform 2 (357aa, 40.2kD). Rat CXCR4 has only one isoform identified so far (349aa, 39.4kD). CXCR4 Antibody is predicted to not cross-react with other CXCR familiy members.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CXCR4
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Knockout Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (86%)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Alternate Names for CXCR4 Antibody [mFluor Violet 500 SE]

  • CD184
  • chemokine (C-X-C motif) receptor 4
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • C-X-C chemokine receptor type 4
  • CXCR4
  • CXC-R4
  • CXCR-4
  • D2S201E
  • D2S201ESDF-1 receptor
  • FB22
  • Fusin
  • HM89
  • HM89NPYRL
  • HSY3RR
  • LAP3
  • LAP-3
  • LCR1
  • LESTR
  • LESTRCD184 antigen
  • Leukocyte-derived seven transmembrane domain receptor
  • leukocyte-derived seven-transmembrane-domain receptor
  • lipopolysaccharide-associated protein 3
  • neuropeptide Y receptor Y3
  • NPY3R
  • NPY3RWHIM
  • NPYR
  • NPYRL
  • NPYY3R
  • pCXCR4
  • seven transmembrane helix receptor
  • seven-transmembrane-segment receptor, spleen
  • Stromal cell-derived factor 1 receptor
  • WHIMS

Background

CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CXCR4 Antibody
[mFluor Violet 500 SE
NBP1-77067MFV500
CXCR4 Antibody [mFluor Violet 500 SE]
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC, KD, KO

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CXCR4 Antibody (NBP1-77067MFV500). (Showing 1 - 1 of 1 FAQ).

  1. Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.
    • CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

Secondary Antibodies

 

Isotype Controls

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Research Areas for CXCR4 Antibody (NBP1-77067MFV500)

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LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m...  Read full blog post.
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The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 li...  Read full blog post.
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mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol CXCR4