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CXCR4 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, Rt, PoSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-76480AF350
Alexa Fluor 405
NBP1-76480AF405
Alexa Fluor 488
NBP1-76480AF488
Alexa Fluor 532
NBP1-76480AF532
Alexa Fluor 594
NBP1-76480AF594
Alexa Fluor 647
NBP1-76480AF647
Alexa Fluor 700
NBP1-76480AF700
Alexa Fluor 750
NBP1-76480AF750
Biotin
NBP1-76480B
CoraFluor 1
NBP1-76480CL1
DyLight 350
NBP1-76480UV
DyLight 488
NBP1-76480G
DyLight 550
NBP1-76480R
DyLight 594
NBP1-76480DL594
DyLight 650
NBP1-76480C
DyLight 680
NBP1-76480FR
DyLight 755
NBP1-76480IR
FITC
NBP1-76480F
HRP
NBP1-76480H
Janelia Fluor 525
NBP1-76480JF525
Janelia Fluor 549
NBP1-76480JF549
Janelia Fluor 585
NBP1-76480JF585
Janelia Fluor 635
NBP1-76480JF635
Janelia Fluor 646
NBP1-76480JF646
Janelia Fluor 669
NBP1-76480JF669
PerCP
NBP1-76480PCP
Unconjugated
NBP1-76480
mFluor Violet 450 SE
NBP1-76480MFV450
mFluor Violet 500 SE
NBP1-76480MFV500
mFluor Violet 610 SE
NBP1-76480MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-76480
BSA Free
NBP1-76480
BSA Free
NBP1-76480-0.025mg
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CXCR4 Antibody [DyLight 405] Summary

Immunogen
Antibody was raised against a peptide corresponding to 15 amino acids near the center of human CXCR4 isoform b. The immunogen is located within amino acids 170-220 of CXCR4. Amino Acid Squence: DRYICDRFYPNDLWV
Specificity
Human CXCR4 has four isoforms, including isoform a (356aa, 40.2kD), isoform b (352aa, 39.7kD), isoform c (423aa, 47.6kD), and isoform d (385aa, 43.4kD). This antibody detects human isoform b only, but not other human isoforms. Mouse CXCR4 has two isoforms, including isoform 1 (359aa, 40.4kD) and isoform 2 (357aa, 40.2kD). Rat CXCR4 has only one isoform identified so far (349aa, 39.4kD).
Predicted Species
Porcine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CXCR4
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (86%), Sheep (86%).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CXCR4 Antibody [DyLight 405]

  • CD184
  • chemokine (C-X-C motif) receptor 4
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • C-X-C chemokine receptor type 4
  • CXCR4
  • CXC-R4
  • CXCR-4
  • D2S201E
  • D2S201ESDF-1 receptor
  • FB22
  • Fusin
  • HM89
  • HM89NPYRL
  • HSY3RR
  • LAP3
  • LAP-3
  • LCR1
  • LESTR
  • LESTRCD184 antigen
  • Leukocyte-derived seven transmembrane domain receptor
  • leukocyte-derived seven-transmembrane-domain receptor
  • lipopolysaccharide-associated protein 3
  • neuropeptide Y receptor Y3
  • NPY3R
  • NPY3RWHIM
  • NPYR
  • NPYRL
  • NPYY3R
  • pCXCR4
  • seven transmembrane helix receptor
  • seven-transmembrane-segment receptor, spleen
  • Stromal cell-derived factor 1 receptor
  • WHIMS

Background

CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CXCR4 Antibody
[DyLight 405]
NBP1-76480V
CXCR4 Antibody [DyLight 405]
Species: Hu, Mu, Rt, Po
Applications: WB, ELISA, ICC/IF, IHC, KD

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CXCR4 Antibody (NBP1-76480V). (Showing 1 - 1 of 1 FAQ).

  1. Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.
    • CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CXCR4