CXCR4 Antibody (44717) [Alexa Fluor® 488]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, ICC.

Showing Publications 1 - 3 of 3.

Publications using FAB173G	Applications	Species
A I?bilir, J Möller, M Arimont, V Bobkov, C Perpiñá-Vi, C Hoffmann, A Inoue, R Heukers, C de Graaf, MJ Smit, P Annibale, MJ Lohse Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists Proc Natl Acad Sci U S A, 2020-11-04;0(0):. 2020-11-04 [PMID: 33148803] (ICC, Human)	ICC	Human
D Sheyn, S Ben-David, W Tawackoli, Z Zhou, K Salehi, M Bez, S De Mel, V Chan, J Roth, P Avalos, JC Giaconi, H Yameen, L Hazanov, D Seliktar, D Li, D Gazit, Z Gazit Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model Theranostics, 2019-10-12;9(25):7506-7524. 2019-10-12 [PMID: 31695783] (Flow Cytometry, Human)	Flow Cytometry	Human
Krook M, Nicholls L, Scannell C, Chugh R, Thomas D, Lawlor E Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res, 2014-03-20;12(6):953-64. 2014-03-20 [PMID: 24651452] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB173G

• CXCR4 Antibodies
• CXCR4 ELISA Kit
• CXCR4 Lysate
• CXCR4 Proteins