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CXCR4 Antibody (44716) [DyLight 755]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, B/N, CyTOF-ready
Clone
44716
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB172U-100UG
Alexa Fluor 405
FAB172V-100UG
Alexa Fluor 488
FAB172G-100UG
Alexa Fluor 532
FAB172X
Alexa Fluor 594
FAB172T-100UG
Alexa Fluor 647
FAB172R-100UG
Alexa Fluor 700
FAB172N-100UG
Alexa Fluor 750
FAB172S-100UG
Allophycocyanin
FAB172A
Allophycocyanin/Cy7
FAB172APCCY7
CoraFluor 1
FAB172CL1
DyLight 350
FAB172D
DyLight 405
FAB172E
DyLight 488
FAB172K
DyLight 550
FAB172L
DyLight 594
FAB172M
DyLight 650
FAB172W
DyLight 680
FAB172Y
FITC
FAB172F
HRP
FAB172H
Janelia Fluor 525
FAB172JF525
Janelia Fluor 549
FAB172I
Janelia Fluor 585
FAB172JF585
Janelia Fluor 635
FAB172JF635
Janelia Fluor 646
FAB172J
Janelia Fluor 669
FAB172JF669
PE
FAB172P
PE/Atto594
FAB172PEATT594
PE/Cy5.5
FAB172PECY55
PE/Cy7
FAB172PECY7
PerCP
FAB172C
Unconjugated
MAB172-100
mFluor Violet 450 SE
FAB172MFV450
mFluor Violet 500 SE
FAB172MFV500
mFluor Violet 610 SE
FAB172MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB172-100
Carrier Free
MAB172-100
Carrier Free
MAB172-SP
Carrier Free
FAB172V-100UG
Carrier Free
FAB172U-100UG
Carrier Free
FAB172T-100UG
Carrier Free
FAB172S-100UG
Carrier Free
FAB172R-100UG
Carrier Free
FAB172N-100UG
Carrier Free
FAB172G-100UG
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CXCR4 Antibody (44716) [DyLight 755] Summary

Immunogen
3T3 cells transfected with human CXCR4
Specificity
Detects human CXCR4. It will also react with cells expressing feline CXCR4 but not rat CXCR4.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CXCR4
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
  • Neutralization
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CXCR4 Antibody (44716) [DyLight 755]

  • CD184
  • chemokine (C-X-C motif) receptor 4
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • C-X-C chemokine receptor type 4
  • CXCR4
  • CXC-R4
  • CXCR-4
  • D2S201E
  • D2S201ESDF-1 receptor
  • FB22
  • Fusin
  • HM89
  • HM89NPYRL
  • HSY3RR
  • LAP3
  • LAP-3
  • LCR1
  • LESTR
  • LESTRCD184 antigen
  • Leukocyte-derived seven transmembrane domain receptor
  • leukocyte-derived seven-transmembrane-domain receptor
  • lipopolysaccharide-associated protein 3
  • neuropeptide Y receptor Y3
  • NPY3R
  • NPY3RWHIM
  • NPYR
  • NPYRL
  • NPYY3R
  • pCXCR4
  • seven transmembrane helix receptor
  • seven-transmembrane-segment receptor, spleen
  • Stromal cell-derived factor 1 receptor
  • WHIMS

Background

CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CXCR4 Antibody
(44716) [DyLight 755]
FAB172Z
CXCR4 Antibody (44716) [DyLight 755]
Species: Hu
Applications: Flow, IHC, B/N, CyTOF-ready

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for CXCR4 Antibody (FAB172Z). (Showing 1 - 1 of 1 FAQ).

  1. Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.
    • CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

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Isotype Controls

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LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m...  Read full blog post.
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The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 li...  Read full blog post.
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Bioinformatics

Gene Symbol CXCR4