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CXCR4 Antibody (374606) [Janelia Fluor® 585]

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Product Details

Summary
Reactivity FeSpecies Glossary
Applications Flow, CyTOF-ready, ICC/IF
Clone
374606
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 585

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB4287U-100UG
Alexa Fluor 405
FAB4287V-100UG
Alexa Fluor 488
FAB4287G-100UG
Alexa Fluor 532
FAB4287X
Alexa Fluor 594
FAB4287T-100UG
Alexa Fluor 647
FAB4287R-100UG
Alexa Fluor 700
FAB4287N-100UG
Alexa Fluor 750
FAB4287S-100UG
Allophycocyanin
FAB4287A
Allophycocyanin/Cy7
FAB4287APCCY7
Biotin
FAB4287B
CoraFluor 1
FAB4287CL1
DyLight 350
FAB4287D
DyLight 405
FAB4287E
DyLight 488
FAB4287K
DyLight 550
FAB4287L
DyLight 594
FAB4287M
DyLight 650
FAB4287W
DyLight 680
FAB4287Y
DyLight 755
FAB4287Z
FITC
FAB4287F
HRP
FAB4287H
Janelia Fluor 525
FAB4287JF525
Janelia Fluor 549
FAB4287I
Janelia Fluor 635
FAB4287JF635
Janelia Fluor 646
FAB4287J
Janelia Fluor 669
FAB4287JF669
PE
FAB4287P
PE/Atto594
FAB4287PEATT594
PE/Cy5.5
FAB4287PECY55
PE/Cy7
FAB4287PECY7
PerCP
FAB4287C
Unconjugated
MAB4287
mFluor Violet 450 SE
FAB4287MFV450
mFluor Violet 500 SE
FAB4287MFV500
mFluor Violet 610 SE
FAB4287MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB4287
Carrier Free
MAB4287
Carrier Free
MAB4287-SP
Carrier Free
FAB4287V-100UG
Carrier Free
FAB4287U-100UG
Carrier Free
FAB4287T-100UG
Carrier Free
FAB4287S-100UG
Carrier Free
FAB4287R-100UG
Carrier Free
FAB4287N-100UG
Carrier Free
FAB4287G-100UG
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CXCR4 Antibody (374606) [Janelia Fluor® 585] Summary

Immunogen
HEK293 human embryonic kidney cell line transfected with feline CXCR4
Met1-Ser353
Accession # P56498
Specificity
Detects feline CXCR4. Stains feline CXCR4 transfectants but not irrelevant transfectants.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CXCR4
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for CXCR4 Antibody (374606) [Janelia Fluor® 585]

  • CD184
  • chemokine (C-X-C motif) receptor 4
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • C-X-C chemokine receptor type 4
  • CXCR4
  • CXC-R4
  • CXCR-4
  • D2S201E
  • D2S201ESDF-1 receptor
  • FB22
  • Fusin
  • HM89
  • HM89NPYRL
  • HSY3RR
  • LAP3
  • LAP-3
  • LCR1
  • LESTR
  • LESTRCD184 antigen
  • Leukocyte-derived seven transmembrane domain receptor
  • leukocyte-derived seven-transmembrane-domain receptor
  • lipopolysaccharide-associated protein 3
  • neuropeptide Y receptor Y3
  • NPY3R
  • NPY3RWHIM
  • NPYR
  • NPYRL
  • NPYY3R
  • pCXCR4
  • seven transmembrane helix receptor
  • seven-transmembrane-segment receptor, spleen
  • Stromal cell-derived factor 1 receptor
  • WHIMS

Background

CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAB4287JF585
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Product General Protocols

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FAQs for CXCR4 Antibody (FAB4287JF585). (Showing 1 - 1 of 1 FAQ).

  1. Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.
    • CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

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Isotype Controls

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Bioinformatics

Gene Symbol CXCR4