COX4-I1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cytochrome c oxidase subunit 4 isoform 1 (COX-4I1) is a 21‑22 kDa member of the cytochrome c oxidase IV family of proteins. It is a component of COX, an inner mitochondrial membrane multimeric dimer that catalyzes the transfer of electrons from cytochrome c to dioxygen. COX-4I1 is the largest of 10 distinct nuclear DNA‑encoded subunits that form each COX monomer. Human COX4-I1 is 169 amino acids (aa) in length and possesses a mitochondrial transit peptide between aa 1‑22, an ATP binding site (aa 42; 95‑100), and multiple subunit interface sequences. The ATP binding site is suggested to make COX-4I1 a regulatory subunit within the COX complex. There are two potential splice variants for COX-4I1 that show a three aa substitution for aa 81‑169, and a single Gly substitution for aa 125‑169. COX‑4I2, the product of a different gene, shares only 50% aa identity with COX-4I1. Over amino acid 23‑169, human COX4‑1 shares 78% aa identity with mouse COX‑4I1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC.

Showing Publications 1 - 3 of 3.

Publications using AF5814	Applications	Species
Trnski S, Nikoli? B, Ilic K et al. The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries Frontiers in Cell and Developmental Biology 2022-02-28 [PMID: 35295859]
Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A. Wheeler, Emily C. Tjon et al. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS Cell 2019-12-01 [PMID: 31813625]
SK Maurya, JL Herrera, SK Sahoo, FCG Reis, RB Vega, DP Kelly, M Periasamy Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle Cell Rep, 2018-09-11;24(11):2919-2931. 2018-09-11 [PMID: 30208317] (IHC, Mouse)	IHC	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	IF	Human and Mouse	09/18/2018	View Summary Application Immunofluorescence Sample Tested NSC-34 cells Species Human and Mouse Lot CDBS021807C Comments Comments PBS 0.01% Triton 0.3% Fish Skin Gelatin

Array AF5814

• COX4-I1 Antibodies
• COX4-I1 ELISA Kits