COX IV Isoform 2 Antibody (1F2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: In vivo assay, WB, Western Blot.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using H00084701-M01	Applications	Species
Liza D, Chaya M, Shmuel R et al. Upregulation of COX4-2 via HIF-1? in Mitochondrial COX4-1 Deficiency. Cells. 2021-02-20 [PMID: 33672589]
Chung YJ, Swietach P, Curtis MK et al. Iron-Deficiency Anemia Results in Transcriptional and Metabolic Remodeling in the Heart Toward a Glycolytic Phenotype Frontiers in Cardiovascular Medicine 2021-01-21 [PMID: 33553263] (In vivo assay)	In vivo assay
Madhu V, Boneski PK, Silagi E et al. Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1?-BNIP3 Axis Journal of Bone and Mineral Research 2020-08-01 [PMID: 32251541] (Western Blot)	Western Blot
Pajuelo D, Cunatova K, Vrbacky M et al. Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity. Cells. 2020-02-14 [PMID: 32075102]
Sun F, Zhuo R, Ma W et al. From clinic to mechanism: Proteomics-based assessment of angiogenesis in adrenal pheochromocytoma J. Cell. Physiol. 2019-05-20 [PMID: 31106414] (Human)		Human
Purandare N, Somayajulu M, Huttemann M et al. The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction. J Biol Chem 2018-04-27 [PMID: 29540477] (Human)		Human
Schiffer TA, Peleli M, Sundqvist ML et al. Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 2016-09-01 [PMID: 27486093]
Cloonan SM, Glass K, Laucho-Contreras ME et al. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med 2016-02-01 [PMID: 26752519]
Aras S, Pak O, Sommer N et al. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Nucleic Acids Res. 2013-01-08 [PMID: 23303788]
Morten KJ, Badder L, Knowles HJ. Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts. J Pathol. 2013-04-01 [PMID: 23303559] (WB, Human)	WB	Human
Huttemann M, Lee I, Gao X et al. Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB J. 2012-09-01 [PMID: 22730437] (WB, Mouse)	WB	Mouse
Sundar Boyalla S, Barbara Victor M, Roemgens A et al. Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability. J Neurosci Res. 2011-05-09 [PMID: 21598289]
Misiak M, Singh S, Drewlo S et al. Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression. Cell Tissue Res 341(1):83-93. 2010-07-01 [PMID: 20602186]
Singh S, Misiak M, Beyer C, Arnold S. Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase. Neurochem Int 57(3):297-305. 2010-10-01 [PMID: 20600440]
Show All 14 Publications. Collapse Publications.

Array H00084701-M01

• COX IV Isoform 2 Antibodies
• COX IV Isoform 2 Lysate
• COX IV Isoform 2 Proteins