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COP9 signalosome complex subunit 2 Antibody

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Biological Strategies: Western Blot: COP9 signalosome complex subunit 2 Antibody [NB100-363] - Detection of Human CSN2 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using ...read more
Immunohistochemistry-Paraffin: COP9 signalosome complex subunit 2 Antibody [NB100-363] - Section of human prostate carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-CSN2 ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Xp, ZeSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
Validated by:
   

Biological Strategies

     

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COP9 signalosome complex subunit 2 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human COP9 constitutive photomorphogenic homolog subunit 2 using the numbering given in entry NP_004227.1 (GeneID 9318).
Predicted Species
Rat (100%), Xenopus (100%), Zebrafish (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
COPS2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:1000 - 1:5000
  • Western Blot 1:1000-1:10000
Application Notes
By Western blot, this antibody recognizes a band at ~50 kDa, representing CSN2 protein. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
Control
COP9 signalosome complex subunit 2 Overexpression Lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for COP9 signalosome complex subunit 2 Antibody

  • Alien homolog
  • ALIEN
  • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
  • COP9 signalosome complex subunit 2
  • CSN2JAB1-containing signalosome subunit 2
  • SGN2TR-interacting protein 15
  • Signalosome subunit 2
  • thyroid receptor interacting protein 15
  • Thyroid receptor-interacting protein 15
  • TRIP15TRIP-15

Background

COP9 signalosome is a conserved protein composed of eight subunits. Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control. CSN2 is a transcriptional corepressor that encodes the second subunit of COP9 signalosome. CSN2 interacts with and regulates a subset of nuclear hormone receptors and is considered a novel repressor. It also plays a critical role in neuronal differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol COPS2
Entrez
Uniprot